P97785 · GFRA1_MOUSE
- ProteinGDNF family receptor alpha-1
- GeneGfra1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids468 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGDNF family receptor alpha-1
- Short namesGDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP97785
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Note: Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MFLATLYFVLPLLDLLMSAEVSGG | ||||||
Chain | PRO_0000010779 | 25-430 | GDNF family receptor alpha-1 | |||
Sequence: DRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDVACTERRRQTIVPVCSYEERERPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRIKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDNDYGKDGLAGASS | ||||||
Disulfide bond | 36↔42 | |||||
Sequence: CLKEQSC | ||||||
Glycosylation | 59 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 154↔214 | |||||
Sequence: CLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFC | ||||||
Disulfide bond | 161↔167 | |||||
Sequence: CNLDDTC | ||||||
Disulfide bond | 178↔192 | |||||
Sequence: CTTSMSNEVCNRRKC | ||||||
Disulfide bond | 187↔233 | |||||
Sequence: CNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDVACTERRRQTIVPVC | ||||||
Disulfide bond | 216↔221 | |||||
Sequence: CRDVAC | ||||||
Disulfide bond | 243↔313 | |||||
Sequence: CLNLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWC | ||||||
Disulfide bond | 250↔256 | |||||
Sequence: CKTNYIC | ||||||
Disulfide bond | 267↔285 | |||||
Sequence: CQPESRSVSNCLKENYADC | ||||||
Disulfide bond | 277↔337 | |||||
Sequence: CLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTC | ||||||
Disulfide bond | 315↔325 | |||||
Sequence: CSNSGNDLEDC | ||||||
Glycosylation | 347 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 406 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 430 | GPI-anchor amidated serine | ||||
Sequence: S | ||||||
Propeptide | PRO_0000010780 | 431-468 | Removed in mature form | |||
Sequence: HITTKSMAAPPSCGLSSLPVMVFTALAALLSVSLAETS |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with GDNF ligand and RET: forms a 2:2:2 ternary complex composed of GDNF ligand, GFRA1 and RET receptor. Interacts with SORL1, either alone or in complex with GDNF. Interaction between SORL1 and GFRA1 leads to GFRA1 internalization, but not degradation.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P97785 | Ret P35546 | 2 | EBI-5549349, EBI-2480800 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 25-113 | 1 | ||||
Sequence: DRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGN | ||||||
Repeat | 150-238 | 2 | ||||
Sequence: KGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDVACTERRRQTIVPVCSYEER | ||||||
Repeat | 239-342 | 3 | ||||
Sequence: ERPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTCLKNAI |
Sequence similarities
Belongs to the GDNFR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
P97785-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsGDNFR-alpha
- Length468
- Mass (Da)51,752
- Last updated2011-07-27 v2
- Checksum997105C2A6DD6446
P97785-2
- Name2
- SynonymsGDNFR-beta
- Differences from canonical
- 140-144: Missing
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D3YUD5 | D3YUD5_MOUSE | Gfra1 | 54 | ||
D3YWL3 | D3YWL3_MOUSE | Gfra1 | 25 | ||
D3Z3C9 | D3Z3C9_MOUSE | Gfra1 | 48 | ||
D6RDD4 | D6RDD4_MOUSE | Gfra1 | 419 | ||
A0A1C7ZN00 | A0A1C7ZN00_MOUSE | Gfra1 | 8 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_041630 | 140-144 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 366 | in Ref. 2; BAA19185 | ||||
Sequence: T → M |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF014117 EMBL· GenBank· DDBJ | AAB86599.1 EMBL· GenBank· DDBJ | mRNA | ||
AF015172 EMBL· GenBank· DDBJ | AAB86600.1 EMBL· GenBank· DDBJ | mRNA | ||
AB000800 EMBL· GenBank· DDBJ | BAA19185.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466585 EMBL· GenBank· DDBJ | EDL01795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH466585 EMBL· GenBank· DDBJ | EDL01796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC054378 EMBL· GenBank· DDBJ | AAH54378.1 EMBL· GenBank· DDBJ | mRNA |