we provide the evidence that the acidic residue (E199) located downstream from the core consensus SUMO site of NR5A1 is at least in part required for SUMOylation of NR5A1 and for its mediated target gene and protein expression.
Changes in the cytoarchitecture of the region of the ventromedial hypothalamus with respect to the distribution of immunoreactive NPY AgRP and CART occur in SF-1 knockouts.
Through a unique interaction between the SF1-positive cortical cells (source of SHH) and SF1-negative capsular cells (targets of SHH) progenitor cells in the adrenal capsule expand.
Results suggest that once SF-1 is bound to DNA sumoylation may be less important in regulating SF-1 activity and that sumoylation imposes an active posttranslational mark that dampens recognition of SUMO-sensitive target genes to restrain expression.
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