P97697 · IMPA1_RAT
- ProteinInositol monophosphatase 1
- GeneImpa1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids277 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity).
Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate
Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate
Catalytic activity
- a myo-inositol phosphate + H2O = myo-inositol + phosphate
Cofactor
Activity regulation
Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li+, Ca2+ and Mn2+, but also by Mg2+ at concentrations above 3 mM.
Pathway
Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 70 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 70 | substrate | ||||
Sequence: E | ||||||
Binding site | 90 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 90 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 92 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 92-95 | substrate | ||||
Sequence: IDGT | ||||||
Binding site | 93 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 194-196 | substrate | ||||
Sequence: GTA | ||||||
Binding site | 213 | substrate | ||||
Sequence: E | ||||||
Binding site | 220 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 220 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cytoplasm | |
Cellular Component | neuronal cell body | |
Molecular Function | identical protein binding | |
Molecular Function | inositol monophosphate 1-phosphatase activity | |
Molecular Function | inositol monophosphate 3-phosphatase activity | |
Molecular Function | inositol monophosphate 4-phosphatase activity | |
Molecular Function | inositol monophosphate phosphatase activity | |
Molecular Function | lithium ion binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | inositol biosynthetic process | |
Biological Process | inositol metabolic process | |
Biological Process | phosphate-containing compound metabolic process | |
Biological Process | phosphatidylinositol biosynthetic process | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol monophosphatase 1
- EC number
- Short namesIMP 1; IMPase 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP97697
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000142517 | 1-277 | Inositol monophosphatase 1 | |||
Sequence: MADPWQECMDYAVILARQAGEMIREALKNKMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPYHSFIGEESVASGEKTVFTEQPTWIIDPIDGTTNFVHRFPFVAVSIGFVVNKEMEFGVVYSCVEDKMYTGRKGKGAFCNGQKLRVSQQEDITKSLLVTELGSSRKPETLRIVLSNMERLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVIEAGGVLLDVTGGPFDLMSRRIIAASNIALAERIAKELEIIPLQRDDES |
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous.
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,511
- Last updated2004-03-01 v2
- Checksum01A7FFB795D2AAED
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1M978 | F1M978_RAT | Impa1 | 330 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U84038 EMBL· GenBank· DDBJ | AAB63338.2 EMBL· GenBank· DDBJ | mRNA |