P97689 · UT1_RAT

  • Protein
    Urea transporter 1
  • Gene
    Slc14a1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:8982255).
Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity).
Facilitates water transport in erythrocytes (By similarity).

Catalytic activity

Features

Showing features for site.

138450100150200250300350
TypeIDPosition(s)Description
Site334Important for channel permeability

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functionurea channel activity
Molecular Functionurea transmembrane transporter activity
Molecular Functionwater transmembrane transporter activity
Biological Processestablishment of localization in cell
Biological Processtransmembrane transport
Biological Processurea transmembrane transport
Biological Processurea transport
Biological Processwater transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Urea transporter 1
  • Alternative names
    • Solute carrier family 14 member 1
    • Urea transporter B (UT-B)
    • Urea transporter, erythrocyte

Gene names

    • Name
      Slc14a1
    • Synonyms
      UT11, UT3

Organism names

  • Taxonomic identifier
  • Strains
    • Sprague-Dawley
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P97689
  • Secondary accessions
    • E9PSP0
    • P70633

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein
Note: Restricted to the basolateral membrane in various portions of the urothelium.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane61-81Helical
Transmembrane85-105Helical
Transmembrane111-131Helical
Transmembrane138-158Helical
Transmembrane168-188Helical
Transmembrane250-270Helical
Transmembrane279-299Helical
Transmembrane305-325Helical
Transmembrane327-347Helical

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004109641-384Urea transporter 1
Glycosylation206N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in brain, spleen, kidney, testis and lung, with highest levels in brain.

Interaction

Subunit

Homotrimer; each subunit contains a pore through which urea permeates (By similarity).
Identified in a complex with STOM (By similarity).

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Sequence similarities

Belongs to the urea transporter family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P97689-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    384
  • Mass (Da)
    42,034
  • Last updated
    2011-06-28 v2
  • Checksum
    1BBD9E8D60CFD6CA
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL

P97689-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MNGQSLSGGTDDSHHDPLWIDPFGNRAGKAAPGGFRRLNLFLAQRWQEQEPEEEMA

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0R8C6M0R8C6_RATSlc14a1404
A0A8I6A939A0A8I6A939_RATSlc14a1369
A0A8I5ZWN6A0A8I5ZWN6_RATSlc14a1440
A0A8J8XP37A0A8J8XP37_RATSlc14a1386

Sequence caution

The sequence CAA67049.1 differs from that shown. Reason: Miscellaneous discrepancy

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0415761in isoform 2
Sequence conflict25in Ref. 1; AAB39937
Sequence conflict47in Ref. 1; AAB39937
Sequence conflict50in Ref. 1; AAB39937
Sequence conflict180in Ref. 1; AAB39937
Sequence conflict266in Ref. 1; AAB39937
Sequence conflict325in Ref. 1; AAB39937
Sequence conflict339in Ref. 1; AAB39937
Sequence conflict378-379in Ref. 1; AAB39937
Sequence conflict382in Ref. 1; AAB39937

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U81518
EMBL· GenBank· DDBJ
AAB39937.1
EMBL· GenBank· DDBJ
mRNA
X98399
EMBL· GenBank· DDBJ
CAA67049.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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