P97493 · THIOM_MOUSE

  • Protein
    Thioredoxin, mitochondrial
  • Gene
    Txn2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.

Features

Showing features for site, active site.

116620406080100120140160
Type
IDPosition(s)Description
Site84Deprotonates C-terminal active site Cys
Active site90Nucleophile
Site91Contributes to redox potential value
Site92Contributes to redox potential value
Active site93Nucleophile

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentmitochondrion
Cellular Componentneuronal cell body
Cellular Componentnucleolus
Molecular Functionpeptide-methionine (R)-S-oxide reductase activity
Molecular Functionpeptide-methionine (S)-S-oxide reductase activity
Molecular Functionprotein-containing complex binding
Molecular Functionprotein-disulfide reductase activity
Biological Processcellular response to nutrient levels
Biological Processresponse to axon injury
Biological Processresponse to glucose
Biological Processresponse to hormone
Biological Processresponse to hypoxia
Biological Processresponse to organic cyclic compound
Biological Processresponse to oxidative stress
Biological Processresponse to xenobiotic stimulus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thioredoxin, mitochondrial
  • Short names
    MTRX; Mt-Trx
  • Alternative names
    • Thioredoxin-2

Gene names

    • Name
      Txn2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • DBA/2J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97493
  • Secondary accessions
    • A2A440
    • Q545D5

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain, disulfide bond, modified residue.

Type
IDPosition(s)Description
Transit peptide1-59Mitochondrion
ChainPRO_000003415160-166Thioredoxin, mitochondrial
Disulfide bond90↔93Redox-active
Modified residue152N6-acetyllysine; alternate
Modified residue152N6-succinyllysine; alternate

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain61-166Thioredoxin

Sequence similarities

Belongs to the thioredoxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    166
  • Mass (Da)
    18,255
  • Last updated
    1997-05-01 v1
  • Checksum
    C9A803DF571F3A7D
MAQRLLLGRFLTSVISRKPPQGVWASLTSKTLQTPQYNAGGLTVMPSPARTVHTTRVCLTTFNVQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAIKNGDVVDKFVGIKDEDQLEAFLKKLIG

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q3TUS3Q3TUS3_MOUSETxn2119
A2A439A2A439_MOUSETxn2149
G3UZY2G3UZY2_MOUSETxn2130
G3UX99G3UX99_MOUSETxn2106

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U85089
EMBL· GenBank· DDBJ
AAB41900.1
EMBL· GenBank· DDBJ
mRNA
AK002358
EMBL· GenBank· DDBJ
BAB22037.1
EMBL· GenBank· DDBJ
mRNA
AK010917
EMBL· GenBank· DDBJ
BAB27267.1
EMBL· GenBank· DDBJ
mRNA
AK147164
EMBL· GenBank· DDBJ
BAE27729.1
EMBL· GenBank· DDBJ
mRNA
AK149855
EMBL· GenBank· DDBJ
BAE29126.1
EMBL· GenBank· DDBJ
mRNA
AK167754
EMBL· GenBank· DDBJ
BAE39789.1
EMBL· GenBank· DDBJ
mRNA
AK167925
EMBL· GenBank· DDBJ
BAE39930.1
EMBL· GenBank· DDBJ
mRNA
AK168322
EMBL· GenBank· DDBJ
BAE40261.1
EMBL· GenBank· DDBJ
mRNA
AL583886
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC068182
EMBL· GenBank· DDBJ
AAH68182.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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