P97493 · THIOM_MOUSE
- ProteinThioredoxin, mitochondrial
- GeneTxn2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids166 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 84 | Deprotonates C-terminal active site Cys | |||
Active site | 90 | Nucleophile | |||
Site | 91 | Contributes to redox potential value | |||
Site | 92 | Contributes to redox potential value | |||
Active site | 93 | Nucleophile | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | mitochondrion | |
Cellular Component | neuronal cell body | |
Cellular Component | nucleolus | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Molecular Function | protein-containing complex binding | |
Molecular Function | protein-disulfide reductase activity | |
Biological Process | cellular response to nutrient levels | |
Biological Process | response to axon injury | |
Biological Process | response to glucose | |
Biological Process | response to hormone | |
Biological Process | response to hypoxia | |
Biological Process | response to organic cyclic compound | |
Biological Process | response to oxidative stress | |
Biological Process | response to xenobiotic stimulus |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThioredoxin, mitochondrial
- Short namesMTRX; Mt-Trx
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP97493
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-59 | Mitochondrion | |||
Chain | PRO_0000034151 | 60-166 | Thioredoxin, mitochondrial | ||
Disulfide bond | 90↔93 | Redox-active | |||
Modified residue | 152 | N6-acetyllysine; alternate | |||
Modified residue | 152 | N6-succinyllysine; alternate | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 61-166 | Thioredoxin | |||
Sequence similarities
Belongs to the thioredoxin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length166
- Mass (Da)18,255
- Last updated1997-05-01 v1
- ChecksumC9A803DF571F3A7D
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U85089 EMBL· GenBank· DDBJ | AAB41900.1 EMBL· GenBank· DDBJ | mRNA | ||
AK002358 EMBL· GenBank· DDBJ | BAB22037.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010917 EMBL· GenBank· DDBJ | BAB27267.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147164 EMBL· GenBank· DDBJ | BAE27729.1 EMBL· GenBank· DDBJ | mRNA | ||
AK149855 EMBL· GenBank· DDBJ | BAE29126.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167754 EMBL· GenBank· DDBJ | BAE39789.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167925 EMBL· GenBank· DDBJ | BAE39930.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168322 EMBL· GenBank· DDBJ | BAE40261.1 EMBL· GenBank· DDBJ | mRNA | ||
AL583886 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC068182 EMBL· GenBank· DDBJ | AAH68182.1 EMBL· GenBank· DDBJ | mRNA |