P97469 · SNAI2_MOUSE

  • Protein
    Zinc finger protein SNAI2
  • Gene
    Snai2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionE-box binding
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcartilage morphogenesis
Biological Processcell migration involved in endocardial cushion formation
Biological Processcellular response to epidermal growth factor stimulus
Biological Processcellular response to ionizing radiation
Biological Processcellular response to platelet-derived growth factor stimulus
Biological Processchromatin organization
Biological Processdesmosome disassembly
Biological Processendothelial cell migration
Biological Processepithelial cell migration
Biological Processepithelial to mesenchymal transition
Biological Processepithelial to mesenchymal transition involved in endocardial cushion formation
Biological Processepithelium development
Biological Processhematopoietic stem cell proliferation
Biological Processmyeloid cell apoptotic process
Biological Processnegative regulation of anoikis
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of cell adhesion involved in substrate-bound cell migration
Biological Processnegative regulation of cell adhesion mediated by integrin
Biological Processnegative regulation of chondrocyte differentiation
Biological Processnegative regulation of DNA damage response, signal transduction by p53 class mediator
Biological Processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processnegative regulation of hematopoietic stem cell proliferation
Biological Processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Biological Processnegative regulation of keratinocyte proliferation
Biological Processnegative regulation of myeloid cell apoptotic process
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of vitamin D biosynthetic process
Biological Processnegative regulation of vitamin D receptor signaling pathway
Biological Processneural crest cell development
Biological ProcessNotch signaling pathway
Biological Processosteoblast differentiation
Biological Processpigmentation
Biological Processpositive regulation of endothelial cell chemotaxis
Biological Processpositive regulation of fat cell differentiation
Biological Processregulation of apoptotic process
Biological Processregulation of bicellular tight junction assembly
Biological Processregulation of branching involved in salivary gland morphogenesis
Biological Processregulation of chemokine production
Biological Processregulation of DNA-templated transcription
Biological Processregulation of osteoblast differentiation
Biological Processresponse to radiation
Biological Processroof of mouth development
Biological Processsensory perception of sound
Biological Processsubstrate-dependent cell migration
Biological Processwhite fat cell differentiation
Biological Processwound healing, spreading of cells

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein SNAI2
  • Alternative names
    • Neural crest transcription factor Slug
    • Protein snail homolog 2

Gene names

    • Name
      Snai2
    • Synonyms
      Slug, Slugh

Organism names

  • Taxonomic identifier
  • Strain
    • 129/Sv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97469
  • Secondary accessions
    • O09096
    • Q9R211

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000470331-269Zinc finger protein SNAI2

Post-translational modification

Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for ubiquitination.
Ubiquitinated by the SCF(FBXO11) complex; ubiquitination requires previous GSK3B-mediated SNAI2 phosphorylation.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Region1-20SNAG domain
Compositional bias81-102Polar residues
Region81-117Disordered
Compositional bias103-117Basic and acidic residues
Zinc finger129-151C2H2-type 1
Zinc finger160-182C2H2-type 2
Zinc finger186-208C2H2-type 3
Zinc finger214-236C2H2-type 4
Zinc finger242-265C2H2-type 5; atypical

Domain

Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    269
  • Mass (Da)
    30,003
  • Last updated
    1997-05-01 v1
  • Checksum
    C61F57779251BEB0
MPRSFLVKKHFNASKKPNYSELDTHTVIISPYLYESYPIPVIPKPEILTSGAYSPITVWTSSAAPLHSPLPSGLSPLTGYSSSLGRVSPPPSSDTSSKDHSGSESPISDEEERLQPKLSDPHAIEAEKFQCNLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias81-102Polar residues
Compositional bias103-117Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U97059
EMBL· GenBank· DDBJ
AAB58704.1
EMBL· GenBank· DDBJ
mRNA
U79550
EMBL· GenBank· DDBJ
AAB38365.1
EMBL· GenBank· DDBJ
mRNA
AF079305
EMBL· GenBank· DDBJ
AAD23913.1
EMBL· GenBank· DDBJ
Genomic DNA
BC062164
EMBL· GenBank· DDBJ
AAH62164.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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