P97468 · CML1_MOUSE
- ProteinChemerin-like receptor 1
- GeneCmklr1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids371 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P97468
The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
- AnnotationThe chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
- CategoryFunction
- SourceGeneRif: 14747
ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
- AnnotationChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
- CategoryFunction
- SourceGeneRif: 14747
Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
- AnnotationResolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
- CategoryFunction
- SourceGeneRif: 14747
n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung- Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
- Annotationn-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
- CategoryFunction
miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
- AnnotationmiR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
- CategoryFunction
- SourceGeneRif: 14747
Behavioral changes in <i>FPR2/ALX</i> and <i>Chemr23</i> receptor knockout mice are exacerbated by prenatal alcohol exposure.
- CategoriesFunction, Sequences
- SourceMGI: 109603
Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
- AnnotationChemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
- CategoriesFunction, Expression, Phenotypes & Variants
- SourceGeneRif: 14747
Chemokine-like receptor 1 plays a critical role in modulating the regenerative and contractile properties of muscle tissue.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 109603
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
- AnnotationChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
- CategoryFunction
The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
- AnnotationThe Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
- CategoryFunction
Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
- AnnotationEpithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
- CategoriesFunction, Expression
The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 109603
Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization.
- CategoryFunction
- SourceMGI: 109603
The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit.
- AnnotationThe chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit.
- CategoriesFunction, Expression
- SourceGeneRif: 14747
Chemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway.
- AnnotationChemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway.
- CategoryFunction
- SourceGeneRif: 14747
The Chemokine-like Receptor 1 Deficiency Improves Cognitive Deficits of AD Mice and Attenuates Tau Hyperphosphorylation via Regulating Tau Seeding.
- AnnotationThe Chemokine-like Receptor 1 Deficiency Improves Cognitive Deficits of AD Mice and Attenuates Tau Hyperphosphorylation via Regulating Tau Seeding.
- CategoriesFunction, Phenotypes & Variants
Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis.
- AnnotationOmega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 14747
CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice.
- AnnotationCMKLR1 deficiency influenced the effect of androgen treatment on adipose tissue by regulating the mRNA expression of the androgen receptor (AR) and adipocyte markers
- CategoriesFunction, Phenotypes & Variants
Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via CMKLR1-dependent natural killer cell recruitment.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 109603
Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report.
- AnnotationChemR23 is expressed on pDCs and macrophages. ChemR23 controls macrophage polarization in atherosclerotic lesions. ChemR23-deficiency decreases CCR7 expression on pDCs and limits their recruitment to atherosclerotic lesions.
- CategoryFunction
- SourceGeneRif: 14747
Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.
- Annotationchemerin/ChemR23 axis played an important role in endothelial injury and inflammation in diabetic nephropathy.
- CategoryFunction
- SourceGeneRif: 14747