P97445 · CAC1A_MOUSE
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- GeneCacna1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2368 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity).
They are however insensitive to dihydropyridines (DHP)
They are however insensitive to dihydropyridines (DHP)
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site, site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP97445
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-100 | Cytoplasmic | ||||
Sequence: MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWP | ||||||
Transmembrane | 101-119 | Helical; Name=S1 of repeat I | ||||
Sequence: PFEYMILATIIANCIVLAL | ||||||
Topological domain | 120-138 | Extracellular | ||||
Sequence: EQHLPDDDKTPMSERLDDT | ||||||
Transmembrane | 139-156 | Helical; Name=S2 of repeat I | ||||
Sequence: EPYFIGIFCFEAGIKIVA | ||||||
Topological domain | 157-168 | Cytoplasmic | ||||
Sequence: LGFAFHKGSYLR | ||||||
Transmembrane | 169-184 | Helical; Name=S3 of repeat I | ||||
Sequence: NGWNVMDFVVVLTGIL | ||||||
Topological domain | 185-192 | Extracellular | ||||
Sequence: ATVGTEFD | ||||||
Transmembrane | 193-211 | Helical; Name=S4 of repeat I | ||||
Sequence: LRTLRAVRVLRPLKLVSGI | ||||||
Topological domain | 212-230 | Cytoplasmic | ||||
Sequence: PSLQVVLKSIMKAMIPLLQ | ||||||
Transmembrane | 231-250 | Helical; Name=S5 of repeat I | ||||
Sequence: IGLLLFFAILIFAIIGLEFY | ||||||
Topological domain | 251-337 | Extracellular | ||||
Sequence: MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTW | ||||||
Transmembrane | 338-362 | Helical; Name=S6 of repeat I | ||||
Sequence: NWLYFIPLIIIGSFFMLNLVLGVLS | ||||||
Topological domain | 363-489 | Cytoplasmic | ||||
Sequence: GEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQ | ||||||
Transmembrane | 490-509 | Helical; Name=S1 of repeat II | ||||
Sequence: AFYWTVLSLVALNTLCVAIV | ||||||
Topological domain | 510-523 | Extracellular | ||||
Sequence: HYNQPEWLSDFLYY | ||||||
Transmembrane | 524-543 | Helical; Name=S2 of repeat II | ||||
Sequence: AEFIFLGLFMSEMFIKMYGL | ||||||
Topological domain | 544-551 | Cytoplasmic | ||||
Sequence: GTRPYFHS | ||||||
Transmembrane | 552-570 | Helical; Name=S3 of repeat II | ||||
Sequence: SFNCFDCGVIIGSIFEVIW | ||||||
Topological domain | 571-580 | Extracellular | ||||
Sequence: AVIKPGTSFG | ||||||
Transmembrane | 581-599 | Helical; Name=S4 of repeat II | ||||
Sequence: ISVLRALRLLRIFKVTKYW | ||||||
Topological domain | 600-618 | Cytoplasmic | ||||
Sequence: ASLRNLVVSLLNSMKSIIS | ||||||
Transmembrane | 619-638 | Helical; Name=S5 of repeat II | ||||
Sequence: LLFLLFLFIVVFALLGMQLF | ||||||
Topological domain | 639-691 | Extracellular | ||||
Sequence: GGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMV | ||||||
Transmembrane | 692-716 | Helical; Name=S6 of repeat II | ||||
Sequence: FSIYFIVLTLFGNYTLLNVFLAIAV | ||||||
Topological domain | 717-1190 | Cytoplasmic | ||||
Sequence: DNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHY | ||||||
Transmembrane | 1191-1214 | Helical; Name=S1 of repeat III | ||||
Sequence: ILNLRYFEMCILMVIAMSSIALAA | ||||||
Topological domain | 1215-1231 | Extracellular | ||||
Sequence: EDPVQPNAPRNNVLRYF | ||||||
Transmembrane | 1232-1251 | Helical; Name=S2 of repeat III | ||||
Sequence: DYVFTGVFTFEMVIKMIDLG | ||||||
Topological domain | 1252-1258 | Cytoplasmic | ||||
Sequence: LVLHQGA | ||||||
Transmembrane | 1259-1282 | Helical; Name=S3 of repeat III | ||||
Sequence: YFRDLWNILDFIVVSGALVAFAFT | ||||||
Topological domain | 1283-1293 | Extracellular | ||||
Sequence: GNSKGKDINTI | ||||||
Transmembrane | 1294-1311 | Helical; Name=S4 of repeat III | ||||
Sequence: KSLRVLRVLRPLKTIKRL | ||||||
Topological domain | 1312-1330 | Cytoplasmic | ||||
Sequence: PKLKAVFDCVVNSLKNVFN | ||||||
Transmembrane | 1331-1350 | Helical; Name=S5 of repeat III | ||||
Sequence: ILIVYMLFMFIFAVVAVQLF | ||||||
Topological domain | 1351-1437 | Extracellular | ||||
Sequence: KGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRME | ||||||
Transmembrane | 1438-1462 | Helical; Name=S6 of repeat III | ||||
Sequence: MSIFYVVYFVVFPFFFVNIFVALII | ||||||
Topological domain | 1463-1518 | Cytoplasmic | ||||
Sequence: ITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPP | ||||||
Transmembrane | 1519-1537 | Helical; Name=S1 of repeat IV | ||||
Sequence: FEYTIMAMIALNTIVLMMK | ||||||
Topological domain | 1538-1551 | Extracellular | ||||
Sequence: FYGASVAYENALRV | ||||||
Transmembrane | 1552-1573 | Helical; Name=S2 of repeat IV | ||||
Sequence: FNIVFTSLFSLECVLKVMAFGI | ||||||
Topological domain | 1574-1580 | Cytoplasmic | ||||
Sequence: LNYFRDA | ||||||
Transmembrane | 1581-1600 | Helical; Name=S3 of repeat IV | ||||
Sequence: WNIFDFVTVLGSITDILVTE | ||||||
Topological domain | 1601-1607 | Extracellular | ||||
Sequence: FGNNFIN | ||||||
Transmembrane | 1608-1626 | Helical; Name=S4 of repeat IV | ||||
Sequence: LSFLRLFRAARLIKLLRQG | ||||||
Topological domain | 1627-1645 | Cytoplasmic | ||||
Sequence: YTIRILLWTFVQSFKALPY | ||||||
Transmembrane | 1646-1665 | Helical; Name=S5 of repeat IV | ||||
Sequence: VCLLIAMLFFIYAIIGMQVF | ||||||
Topological domain | 1666-1737 | Extracellular | ||||
Sequence: GNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTADCGNEF | ||||||
Transmembrane | 1738-1763 | Helical; Name=S6 of repeat IV | ||||
Sequence: AYFYFVSFIFLCSFLMLNLFVAVIMD | ||||||
Topological domain | 1764-2368 | Cytoplasmic | ||||
Sequence: NFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC |
Keywords
- Cellular component
Phenotypes & Variants
Involvement in disease
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 649 | in tg | ||||
Sequence: P → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 85 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053917 | 1-2368 | Voltage-dependent P/Q-type calcium channel subunit alpha-1A | |||
Sequence: MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC | ||||||
Glycosylation | 285 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 411 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 450 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 453 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 752 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 755 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 792 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1038 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1042 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1051 | Phosphoserine | ||||
Sequence: S | ||||||
Glycosylation | 1607 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 1935 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1998 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2016 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2028 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2030 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2071 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 2091 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Brain specific; mainly found in the cerebellum, olfactory bulb, cerebral cortex, hippocampus, and inferior colliculus. In the hippocampus, expression occurs in pyramidal and granule neurons, as well as in interneurons. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
Gene expression databases
Interaction
Subunit
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 (By similarity).
Interacts with the spider omega-agatoxin-IVA (AC P30288) (By similarity).
Interacts with TSPOAP1 (By similarity).
Interacts with the spider omega-agatoxin-IVA (AC P30288) (By similarity).
Interacts with TSPOAP1 (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 65-365 | I | ||||
Sequence: NPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF | ||||||
Region | 385-402 | Binding to the beta subunit | ||||
Sequence: QQIERELNGYMEWISKAE | ||||||
Repeat | 475-719 | II | ||||
Sequence: ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNL | ||||||
Region | 762-781 | Disordered | ||||
Sequence: AVKEQQKNQKPTKSVWEQRT | ||||||
Region | 823-1117 | Disordered | ||||
Sequence: PLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPE | ||||||
Compositional bias | 828-842 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAP | ||||||
Compositional bias | 845-864 | Basic and acidic residues | ||||
Sequence: LRPTARPRESARDPDARRAW | ||||||
Compositional bias | 874-991 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQ | ||||||
Compositional bias | 994-1011 | Polar residues | ||||
Sequence: GVPVSGPNLSTTRPIQQD | ||||||
Compositional bias | 1052-1081 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1092-1112 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Region | 1137-1170 | Disordered | ||||
Sequence: VNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMP | ||||||
Compositional bias | 1144-1164 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Repeat | 1182-1465 | III | ||||
Sequence: NPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF | ||||||
Repeat | 1502-1765 | IV | ||||
Sequence: NKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF | ||||||
Region | 1940-2368 | Disordered | ||||
Sequence: QRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC | ||||||
Compositional bias | 1947-1962 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 1981-1995 | Polar residues | ||||
Sequence: SWVTQRAQEMFQKTG | ||||||
Compositional bias | 2007-2021 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2086-2105 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2156-2173 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2174-2210 | Basic and acidic residues | ||||
Sequence: APDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTH | ||||||
Compositional bias | 2211-2245 | Polar residues | ||||
Sequence: RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTP | ||||||
Compositional bias | 2351-2368 | Basic and acidic residues | ||||
Sequence: TARRGAHDAYSESEDDWC |
Domain
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,368
- Mass (Da)267,647
- Last updated2007-02-06 v2
- ChecksumE7B573BA005E5CB1
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9Q1R5 | E9Q1R5_MOUSE | Cacna1a | 2321 | ||
A0A571BE75 | A0A571BE75_MOUSE | Cacna1a | 183 | ||
A0A571BET0 | A0A571BET0_MOUSE | Cacna1a | 2457 | ||
A0A571BEF0 | A0A571BEF0_MOUSE | Cacna1a | 776 | ||
A0A1L1SQZ2 | A0A1L1SQZ2_MOUSE | Cacna1a | 2321 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 79 | in Ref. 2; AAC52940 | ||||
Sequence: S → P | ||||||
Sequence conflict | 82 | in Ref. 2; AAC52940 | ||||
Sequence: L → F | ||||||
Compositional bias | 828-842 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAP | ||||||
Compositional bias | 845-864 | Basic and acidic residues | ||||
Sequence: LRPTARPRESARDPDARRAW | ||||||
Compositional bias | 874-991 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQ | ||||||
Sequence conflict | 884 | in Ref. 2; AAC52940 | ||||
Sequence: P → L | ||||||
Sequence conflict | 888 | in Ref. 1; AAW56205 | ||||
Sequence: E → D | ||||||
Compositional bias | 994-1011 | Polar residues | ||||
Sequence: GVPVSGPNLSTTRPIQQD | ||||||
Compositional bias | 1052-1081 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Sequence conflict | 1083 | in Ref. 2; AAC52940 | ||||
Sequence: N → D | ||||||
Compositional bias | 1092-1112 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Compositional bias | 1144-1164 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Sequence conflict | 1349 | in Ref. 2; AAC52940 | ||||
Sequence: L → F | ||||||
Sequence conflict | 1373 | in Ref. 2; AAC52940 | ||||
Sequence: L → F | ||||||
Compositional bias | 1947-1962 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 1981-1995 | Polar residues | ||||
Sequence: SWVTQRAQEMFQKTG | ||||||
Compositional bias | 2007-2021 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2086-2105 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2156-2173 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Sequence conflict | 2161 | in Ref. 1; AAW56205 | ||||
Sequence: P → PH | ||||||
Compositional bias | 2174-2210 | Basic and acidic residues | ||||
Sequence: APDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTH | ||||||
Compositional bias | 2211-2245 | Polar residues | ||||
Sequence: RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTP | ||||||
Compositional bias | 2351-2368 | Basic and acidic residues | ||||
Sequence: TARRGAHDAYSESEDDWC |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY714490 EMBL· GenBank· DDBJ | AAW56205.1 EMBL· GenBank· DDBJ | mRNA | ||
U76716 EMBL· GenBank· DDBJ | AAC52940.1 EMBL· GenBank· DDBJ | mRNA |