P97411 · ICA69_MOUSE

  • Protein
    Islet cell autoantigen 1
  • Gene
    Ica1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role in neurotransmitter secretion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular ComponentGolgi stack
Cellular Componentperinuclear region of cytoplasm
Cellular Componentsecretory granule membrane
Cellular Componentsynaptic vesicle membrane
Molecular Functionmembrane curvature sensor activity
Molecular Functionprotein domain specific binding
Biological Processneurotransmitter transport
Biological Processregulation of neurotransmitter secretion
Biological Processregulation of protein-containing complex assembly
Biological Processregulation of transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Islet cell autoantigen 1
  • Alternative names
    • 69 kDa islet cell autoantigen (ICA69)
    • Islet cell autoantigen p69 (ICAp69; p69)

Gene names

    • Name
      Ica1
    • Synonyms
      Icap69

Organism names

  • Taxonomic identifier
  • Strains
    • NOD
    • C57BL/6J
    • BALB/cJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97411
  • Secondary accessions
    • E9QLS3
    • P97362
    • P97954
    • Q99M40
    • Q9R2C4

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, cytosol
Golgi apparatus membrane
; Peripheral membrane protein
Cytoplasmic vesicle, secretory vesicle membrane
; Peripheral membrane protein
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
; Peripheral membrane protein
Note: Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

Keywords

Phenotypes & Variants

Disruption phenotype

129/SvJ mice lacking Ica1 do not display an obvious phenotype and age normally, while NOD mice without Ica1 develop diabetes and display sudden mid-life lethality but are resistant to cyclophosphamide-induced disease acceleration.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 28 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000841311-478Islet cell autoantigen 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis.

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P97411Pick1 Q620832EBI-16056188, EBI-77550

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain50-253AH
Region306-365Disordered
Compositional bias315-330Polar residues
Region398-422Disordered

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

P97411-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Alpha
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    478
  • Mass (Da)
    54,324
  • Last updated
    2011-07-27 v3
  • Checksum
    B7B1EE18AC39E2F9
MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA

P97411-2

  • Name
    2
  • Synonyms
    Beta
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7BG11F7BG11_MOUSEIca1141
F6UY19F6UY19_MOUSEIca166
D3Z699D3Z699_MOUSEIca145
D3Z118D3Z118_MOUSEIca1465
D3Z119D3Z119_MOUSEIca1310
S4R217S4R217_MOUSEIca1302
D3Z376D3Z376_MOUSEIca1277
D3Z020D3Z020_MOUSEIca173

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict170in Ref. 1; AAB19182
Sequence conflict312in Ref. 1; AAB19182/AAC52992/AAC52993/AAB40939, 4; AAH02030 and 5; AAC99989
Alternative sequenceVSP_050425315in isoform 2
Compositional bias315-330Polar residues
Alternative sequenceVSP_050426316-336in isoform 2
Sequence conflict397in Ref. 1; AAB19182/AAC52992/AAC52993/AAB40939, 4; AAH02030 and 5; AAC99989

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U26459
EMBL· GenBank· DDBJ
AAC52992.1
EMBL· GenBank· DDBJ
mRNA
U26460
EMBL· GenBank· DDBJ
AAB40939.1
EMBL· GenBank· DDBJ
mRNA
U26461
EMBL· GenBank· DDBJ
AAC52993.1
EMBL· GenBank· DDBJ
mRNA
U37186
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37013
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37014
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37015
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37082
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37083
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37084
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37085
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37086
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37184
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
U37185
EMBL· GenBank· DDBJ
AAB19182.1
EMBL· GenBank· DDBJ
Genomic DNA
AC158670
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC002030
EMBL· GenBank· DDBJ
AAH02030.1
EMBL· GenBank· DDBJ
mRNA
U34595
EMBL· GenBank· DDBJ
AAC99989.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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