P97411 · ICA69_MOUSE
- ProteinIslet cell autoantigen 1
- GeneIca1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids478 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play a role in neurotransmitter secretion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | dendrite | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | Golgi stack | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | secretory granule membrane | |
Cellular Component | synaptic vesicle membrane | |
Molecular Function | membrane curvature sensor activity | |
Molecular Function | protein domain specific binding | |
Biological Process | neurotransmitter transport | |
Biological Process | regulation of neurotransmitter secretion | |
Biological Process | regulation of protein-containing complex assembly | |
Biological Process | regulation of transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameIslet cell autoantigen 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP97411
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein
Note: Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
129/SvJ mice lacking Ica1 do not display an obvious phenotype and age normally, while NOD mice without Ica1 develop diabetes and display sudden mid-life lethality but are resistant to cyclophosphamide-induced disease acceleration.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 28 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000084131 | 1-478 | Islet cell autoantigen 1 | |||
Sequence: MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEGKKTSWRENREAVAPEPRQLISLEDEHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPEEACLGPTAGTPEPESGDKDDLLLLNEIFSTSCLDEGEFSREWAAVFGDDQLKEPAPMGAQGEPDPKPQIGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA |
Proteomic databases
PTM databases
Expression
Tissue specificity
Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P97411 | Pick1 Q62083 | 2 | EBI-16056188, EBI-77550 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-253 | AH | ||||
Sequence: ASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQYRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHE | ||||||
Region | 306-365 | Disordered | ||||
Sequence: EHKDSSAYKTEEGTSVLSSVDKGSVHDTCSGPIDELLDGKPEEACLGPTAGTPEPESGDK | ||||||
Compositional bias | 315-330 | Polar residues | ||||
Sequence: TEEGTSVLSSVDKGSV | ||||||
Region | 398-422 | Disordered | ||||
Sequence: LKEPAPMGAQGEPDPKPQIGSGFLP |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
P97411-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsAlpha
- Length478
- Mass (Da)54,324
- Last updated2011-07-27 v3
- ChecksumB7B1EE18AC39E2F9
P97411-2
- Name2
- SynonymsBeta
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 170 | in Ref. 1; AAB19182 | ||||
Sequence: L → F | ||||||
Sequence conflict | 312 | in Ref. 1; AAB19182/AAC52992/AAC52993/AAB40939, 4; AAH02030 and 5; AAC99989 | ||||
Sequence: A → T | ||||||
Alternative sequence | VSP_050425 | 315 | in isoform 2 | |||
Sequence: T → R | ||||||
Compositional bias | 315-330 | Polar residues | ||||
Sequence: TEEGTSVLSSVDKGSV | ||||||
Alternative sequence | VSP_050426 | 316-336 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 397 | in Ref. 1; AAB19182/AAC52992/AAC52993/AAB40939, 4; AAH02030 and 5; AAC99989 | ||||
Sequence: Q → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U26459 EMBL· GenBank· DDBJ | AAC52992.1 EMBL· GenBank· DDBJ | mRNA | ||
U26460 EMBL· GenBank· DDBJ | AAB40939.1 EMBL· GenBank· DDBJ | mRNA | ||
U26461 EMBL· GenBank· DDBJ | AAC52993.1 EMBL· GenBank· DDBJ | mRNA | ||
U37186 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37013 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37014 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37015 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37082 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37083 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37084 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37085 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37086 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37184 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U37185 EMBL· GenBank· DDBJ | AAB19182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC158670 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC002030 EMBL· GenBank· DDBJ | AAH02030.1 EMBL· GenBank· DDBJ | mRNA | ||
U34595 EMBL· GenBank· DDBJ | AAC99989.1 EMBL· GenBank· DDBJ | mRNA |