P97402 · GCNT2_MOUSE

  • Protein
    N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
  • Gene
    Gcnt2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi membrane
Molecular Functionacetylglucosaminyltransferase activity
Molecular FunctionN-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of epithelial to mesenchymal transition
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpost-transcriptional regulation of gene expression
Biological Processprotein glycosylation
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
  • EC number
  • Short names
    N-acetylglucosaminyltransferase
  • Alternative names
    • I-branching enzyme
    • IGNT
    • Large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase

Gene names

    • Name
      Gcnt2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97402
  • Secondary accessions
    • Q6T5E3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Cytoplasmic
Transmembrane8-28Helical; Signal-anchor for type II membrane protein
Topological domain29-401Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00001913981-401N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Glycosylation37N-linked (GlcNAc...) asparagine
Glycosylation255N-linked (GlcNAc...) asparagine
Glycosylation315N-linked (GlcNAc...) asparagine
Glycosylation389N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 14 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    401
  • Mass (Da)
    45,697
  • Last updated
    2013-09-18 v2
  • Checksum
    4DBD498E6EEEDF13
MPPSVRYFFIVSVTTVIVFIVLYVLSFGGDQSYQKLNISDSVMLAQVCSSFIDGKSRFLWRNKLMIHEKPSCTEYVTQSHYITAPLSQEEVDFPLAYVMVIHHNFDTFARLFRAIFMPQNIYCVHVDEKATAEFKGAVEQLVSCFPNAFLASKMEPVVYGGISRLQADLNCIKDLSTSEVPWKYAINTCGQDFPLKTNKEIVQYLKGLKGKNLTPGVLPPAHAIGRTRYVHREHLSKELSYVIRTTALKPPPPHNLTIYFGSAYVALSREFANFVLRDPRAVDLLHWSKDTFSPDEHFWVTLNRIPGVPGSMPPNASWTGNLRAVKWMDMEAKHGGCHGHYVHGICIYGNGDLQWLINSQSLFANKFELNTYPLTVECLELRLRERTLNQSEIAIQPSWYF

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q7TPQ8Q7TPQ8_MOUSEGcnt2401
A0A286YDC7A0A286YDC7_MOUSEGcnt245
Q6T5E4Q6T5E4_MOUSEGcnt2401
Q9D2A8Q9D2A8_MOUSEGcnt2356

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict3in Ref. 1; AAB39621
Sequence conflict17-22in Ref. 1; AAB39621
Sequence conflict43-45in Ref. 1; AAB39621
Sequence conflict91in Ref. 1; AAB39621
Sequence conflict148in Ref. 1; AAB39621
Sequence conflict312in Ref. 1; AAB39621
Sequence conflict338in Ref. 1; AAB39621
Sequence conflict393in Ref. 1; AAB39621

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U68182
EMBL· GenBank· DDBJ
AAB39621.1
EMBL· GenBank· DDBJ
mRNA
AY435149
EMBL· GenBank· DDBJ
AAR95650.1
EMBL· GenBank· DDBJ
mRNA
AC133496
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC159205
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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