P97314 · CSRP2_MOUSE

  • Protein
    Cysteine and glycine-rich protein 2
  • Gene
    Csrp2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Biological Processcell differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine and glycine-rich protein 2
  • Alternative names
    • Cysteine-rich protein 2 (CRP2)
    • Double LIM protein 1 (DLP-1)

Gene names

    • Name
      Csrp2
    • Synonyms
      Dlp1

Organism names

  • Taxonomic identifier
  • Strains
    • C3H/HeJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97314
  • Secondary accessions
    • Q9CZG5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), cross-link, modified residue.

Type
IDPosition(s)Source
Description
ChainPRO_00000757221-193UniProtCysteine and glycine-rich protein 2
Modified residue (large scale data)57PTMeXchangePhosphotyrosine
Modified residue (large scale data)79PTMeXchangePhosphothreonine
Cross-link91UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue112UniProtN6-acetyllysine
Modified residue131UniProtN6-acetyllysine
Modified residue137UniProtN6-acetyllysine; alternate
Modified residue137UniProtN6-succinyllysine; alternate
Modified residue161UniProtN6-acetyllysine
Modified residue (large scale data)182PTMeXchangePhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction (By similarity).
Interacts with GLRX3

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, motif.

Type
IDPosition(s)Description
Domain10-61LIM zinc-binding 1
Motif64-69Nuclear localization signal
Domain119-170LIM zinc-binding 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    20,926
  • Last updated
    2007-01-23 v3
  • MD5 Checksum
    4B6598B16DF38D685770D6260D840F02
MPVWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDEEIYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESAQPHRPTTNPNTSKFAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W2P6I3A0A1W2P6I3_MOUSECsrp2114
A0A1W2P758A0A1W2P758_MOUSECsrp2136
A0A1W2P780A0A1W2P780_MOUSECsrp259
A0A1W2P7N8A0A1W2P7N8_MOUSECsrp284
A0A1W2P845A0A1W2P845_MOUSECsrp2197

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict30in Ref. 1; BAB28379

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D88792
EMBL· GenBank· DDBJ
BAA13722.1
EMBL· GenBank· DDBJ
mRNA
AK010626
EMBL· GenBank· DDBJ
BAB27072.1
EMBL· GenBank· DDBJ
mRNA
AK012647
EMBL· GenBank· DDBJ
BAB28379.1
EMBL· GenBank· DDBJ
mRNA
BC012663
EMBL· GenBank· DDBJ
AAH12663.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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