P97291 · CADH8_MOUSE

  • Protein
    Cadherin-8
  • Gene
    Cdh8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentaxon terminus
Cellular Componentcatenin complex
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentsynaptic cleft
Cellular Componentsynaptic membrane
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Molecular Functioncalcium ion binding
Molecular Functionidentical protein binding
Biological Processadherens junction organization
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processcell migration
Biological Processcell morphogenesis
Biological Processcell-cell adhesion mediated by cadherin
Biological Processcell-cell junction assembly
Biological Processchemical synaptic transmission
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules
Biological Processregulation of synapse organization
Biological Processresponse to cold
Biological Processsynaptic transmission, glutamatergic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cadherin-8

Gene names

    • Name
      Cdh8

Organism names

  • Taxonomic identifier
  • Strains
    • Swiss Webster / NIH
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97291
  • Secondary accessions
    • G3UVU4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain62-621Extracellular
Transmembrane622-642Helical
Topological domain643-799Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-29
PropeptidePRO_000000377530-61
ChainPRO_000000377662-799Cadherin-8
Glycosylation188N-linked (GlcNAc...) asparagine
Glycosylation463N-linked (GlcNAc...) asparagine
Glycosylation473N-linked (GlcNAc...) asparagine
Glycosylation544N-linked (GlcNAc...) asparagine
Modified residue795Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P97291Cdh8 P972912EBI-15719457, EBI-15719457

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain62-167Cadherin 1
Domain168-276Cadherin 2
Domain277-391Cadherin 3
Domain392-494Cadherin 4
Domain495-616Cadherin 5

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    799
  • Mass (Da)
    88,215
  • Last updated
    2012-10-03 v2
  • Checksum
    0EF1285E5DD67F76
MPERLAETLMDLWTPLIILWITLPSCVYTAPMNQAHVLTTGSPLELSRQSEDMRILSRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSSRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKET

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PYB2E9PYB2_MOUSECdh8711
E9PZC1E9PZC1_MOUSECdh8247
E9Q451E9Q451_MOUSECdh8754
Q8C449Q8C449_MOUSECdh8716
D6RG94D6RG94_MOUSECdh8509

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict247in Ref. 1; CAA64857

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X95600
EMBL· GenBank· DDBJ
CAA64857.1
EMBL· GenBank· DDBJ
mRNA
AC102643
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC103397
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC162519
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC162867
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466525
EMBL· GenBank· DDBJ
EDL11191.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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