P96786 · FLID_HELPY
- ProteinFlagellar hook-associated protein 2
- GenefliD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids685 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential to colonize and establish infection in gastric mucosa as a result of its essential role in motility. Has effect on flaA gene transcription.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | bacterial-type flagellum | |
Cellular Component | bacterial-type flagellum filament cap | |
Cellular Component | bacterial-type flagellum hook | |
Cellular Component | extracellular region | |
Biological Process | bacterial-type flagellum-dependent cell motility | |
Biological Process | bacterial-type flagellum-dependent swarming motility | |
Biological Process | cell adhesion |
Names & Taxonomy
Protein names
- Recommended nameFlagellar hook-associated protein 2
- Short namesHAP2
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionP96786
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 59 | in strain: KCTC 0217BP | ||||
Sequence: A → S | ||||||
Natural variant | 86 | in strain: KCTC 0217BP | ||||
Sequence: S → N | ||||||
Natural variant | 91 | in strain: KCTC 0217BP | ||||
Sequence: V → A | ||||||
Natural variant | 193 | in strain: KCTC 0217BP | ||||
Sequence: V → I | ||||||
Natural variant | 231 | in strain: KCTC 0217BP | ||||
Sequence: N → S | ||||||
Natural variant | 258 | in strain: KCTC 0217BP | ||||
Sequence: M → I | ||||||
Natural variant | 270 | in strain: KCTC 0217BP | ||||
Sequence: N → D | ||||||
Natural variant | 363 | in strain: KCTC 0217BP | ||||
Sequence: I → V | ||||||
Natural variant | 368 | in strain: KCTC 0217BP | ||||
Sequence: A → S | ||||||
Natural variant | 373 | in strain: KCTC 0217BP | ||||
Sequence: S → N | ||||||
Natural variant | 422 | in strain: KCTC 0217BP | ||||
Sequence: N → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000177019 | 2-685 | Flagellar hook-associated protein 2 | |||
Sequence: AIGSLSSLGLGSKVLNYDVIDKLKDADEKALIAPLDKKMEQNVEKQKALVEIKTLLSALKGPVKTLSDYSTYISRKSNVTGDALSASVGVGVPIQDIKVDVQNLAQGDINELGAKFSSRDDIFSQVDTTLKFYTQNKDYAVNIKAGMTLGDVAQSITDATNGEVMGIVMKTGGNDPYQLMVNTKNTGEDNRVYFGSHLQSTLTNKNALSLGVDGSGKSEVSLNLKGADGNMHEVPIMLELPESASIKQKNTAIQKAMEQALENDPNFKNLIANGDISIDTLHGGESLIINDRRGGNIEVKGSKAKELGFLQTTTQESDLLKSSRTIKEGKLEGVVSLNGQKLDLSALTKESNTSEENTDAIIQAINAKEGLSAFKNAEGKLVINSKTGMLTIKGEDALGKASLKDLGLNAGMVQSYEASQNTLFMSKNLQKASDSAFTYNGVSITRPTNEVNDVISGVNITLEQTTEPNKPAIISVSRDNQAIIDSLTEFVKAYNELIPKLDEDTRYDADTKIAGIFNGVGDIRAIRSSLNNVFSYSVHTDNGVESLMKYGLSLDDKGVMSLDEAKLSSALNSNPKATQDFFYGSDSKDMGGREIHQEGIFSKFNQVIANLIDGGNAKLKIYEDSLDRDAKSLTKDKENAQELLKTRYNIMAERFAAYDSQISKANQKFNSVQMMIDQAAAKKN |
Proteomic databases
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 618-647 | |||||
Sequence: AKLKIYEDSLDRDAKSLTKDKENAQELLKT |
Sequence similarities
Belongs to the FliD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length685
- Mass (Da)74,131
- Last updated2007-01-23 v4
- Checksum12D4F56473D047F6
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 654-685 | in Ref. 2; AAD07800 | ||||
Sequence: ERFAAYDSQISKANQKFNSVQMMIDQAAAKKN → DVLPLMIAKSLKPIKNSIPCK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U82981 EMBL· GenBank· DDBJ | AAC35999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE000511 EMBL· GenBank· DDBJ | AAD07800.1 EMBL· GenBank· DDBJ | Genomic DNA |