P95872 · RIB7_SACS2

Function

function

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site53NADP+ (UniProtKB | ChEBI)
Binding site57NADP+ (UniProtKB | ChEBI)
Binding site79-82NADP+ (UniProtKB | ChEBI)
Binding site122NADP+ (UniProtKB | ChEBI)
Binding site145-148NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-amino-6-(5-phosphoribosylamino)uracil reductase activity
Molecular FunctionNADP binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
  • EC number
  • Short names
    DAROPP reductase; DARP reductase
  • Alternative names
    • 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase
    • 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase (DARIPP synthase)

Gene names

    • ORF names
      C06025, C06_008
    • Ordered locus names
      SSO2097

Organism names

Accessions

  • Primary accession
    P95872

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001359461-2132,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the HTP reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    213
  • Mass (Da)
    24,561
  • Last updated
    1997-05-01 v1
  • Checksum
    A741F6CADEF7631C
MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYGKNRRNPIRVVVTRSFNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRKFLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDEIRITISPRIFGNGVSFTQGEGFIGEDSPRLELIDAKICECGNEVHLTYKKYMT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y08256
EMBL· GenBank· DDBJ
CAA69508.1
EMBL· GenBank· DDBJ
Genomic DNA
AE006641
EMBL· GenBank· DDBJ
AAK42277.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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