P94077 · LSD1_ARATH
- ProteinProtein LSD1
- GeneLSD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids189 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy.
Miscellaneous
When expressed in Arabidopsis, Pisum sativa LSD1 interacts with importin alpha via the LSD1-type zinc finger motifs, suggesting that the nuclear import of LSD1 may rely on the interaction between its zinc finger motifs and importin alpha.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | apoptotic process | |
Biological Process | negative regulation of programmed cell death | |
Biological Process | plant-type hypersensitive response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein LSD1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP94077
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Disruption phenotype
No visible phenotype under normal growth condition, however cold treatment induces the development of yellowish leaves with necrosis, and treatment with salicylic acid or infection with avirulent pathogen causes a runaway cell death and plant death.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000408483 | 1-189 | Protein LSD1 | ||
Proteomic databases
Expression
Tissue specificity
Expressed in cotyledons, roots, rosette leaves, stems, inflorescences and flowers.
Induction
By methyl viologen.
Gene expression databases
Interaction
Subunit
Interacts with BZIP10 and AMC1 (via N-terminus). Binds to BZIP63. Interacts with CAT1, CAT2 and CAT3 in a zinc-finger-dependent manner (PubMed:23958864).
Interacts (via N-terminus) with GILP (PubMed:21526181).
Interacts (via N-terminus) with GILP (PubMed:21526181).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P94077 | AMC1 Q7XJE6 | 3 | EBI-5849461, EBI-5849501 | |
BINARY | P94077 | BBX26 O80748 | 3 | EBI-5849461, EBI-15191535 | |
BINARY | P94077 | DRP3A Q8S944 | 7 | EBI-5849461, EBI-2265428 | |
BINARY | P94077 | DRP3B Q8LFT2 | 3 | EBI-5849461, EBI-2265511 | |
BINARY | P94077 | ERF12 Q94ID6 | 3 | EBI-5849461, EBI-4446727 | |
BINARY | P94077 | GILP Q94CD4 | 3 | EBI-5849461, EBI-6274018 | |
BINARY | P94077 | NFYC8 Q4PSE2 | 4 | EBI-5849461, EBI-15191571 | |
BINARY | P94077 | NFYC9 Q8L4B2 | 4 | EBI-5849461, EBI-2466050 | |
BINARY | P94077 | SRM1 Q9FNN6 | 5 | EBI-5849461, EBI-15195055 | |
BINARY | P94077 | ZIP10 Q8W245 | 3 | EBI-5849461, EBI-6956003 |
Protein-protein interaction databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
P94077-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length189
- Mass (Da)20,107
- Last updated1997-05-01 v1
- Checksum5EBEE628A30F1550
P94077-2
- Name2
- Differences from canonical
- 1-5: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4JUW0 | F4JUW0_ARATH | LSD1 | 210 | ||
A0A1P8B450 | A0A1P8B450_ARATH | LSD1 | 129 |
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_041104 | 1-5 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U87833 EMBL· GenBank· DDBJ | AAC49660.1 EMBL· GenBank· DDBJ | mRNA | ||
U87834 EMBL· GenBank· DDBJ | AAC49661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL080253 EMBL· GenBank· DDBJ | CAB45804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161553 EMBL· GenBank· DDBJ | CAB79038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84318.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE84321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY080824 EMBL· GenBank· DDBJ | AAL87301.1 EMBL· GenBank· DDBJ | mRNA | ||
AY117316 EMBL· GenBank· DDBJ | AAM51391.1 EMBL· GenBank· DDBJ | mRNA | ||
AK318980 EMBL· GenBank· DDBJ | BAH57095.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AY087794 EMBL· GenBank· DDBJ | AAM65330.1 EMBL· GenBank· DDBJ | mRNA |