P94077 · LSD1_ARATH

Function

function

Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy.

Miscellaneous

When expressed in Arabidopsis, Pisum sativa LSD1 interacts with importin alpha via the LSD1-type zinc finger motifs, suggesting that the nuclear import of LSD1 may rely on the interaction between its zinc finger motifs and importin alpha.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Biological Processapoptotic process
Biological Processnegative regulation of programmed cell death
Biological Processplant-type hypersensitive response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein LSD1
  • Alternative names
    • Protein CHILLING SENSITIVE 4
    • Protein LESION SIMULATING DISEASE 1 (AtLSD1)
    • Putative zinc finger LSD1

Gene names

    • Name
      LSD1
    • Synonyms
      CHS4
    • ORF names
      F9F13.30
    • Ordered locus names
      At4g20380

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Wassilewskija
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P94077
  • Secondary accessions
    • C0Z316
    • Q8RXL2

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth condition, however cold treatment induces the development of yellowish leaves with necrosis, and treatment with salicylic acid or infection with avirulent pathogen causes a runaway cell death and plant death.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004084831-189Protein LSD1

Proteomic databases

Expression

Tissue specificity

Expressed in cotyledons, roots, rosette leaves, stems, inflorescences and flowers.

Induction

By methyl viologen.

Gene expression databases

Interaction

Subunit

Interacts with BZIP10 and AMC1 (via N-terminus). Binds to BZIP63. Interacts with CAT1, CAT2 and CAT3 in a zinc-finger-dependent manner (PubMed:23958864).
Interacts (via N-terminus) with GILP (PubMed:21526181).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P94077AMC1 Q7XJE63EBI-5849461, EBI-5849501
BINARY P94077BBX26 O807483EBI-5849461, EBI-15191535
BINARY P94077DRP3A Q8S9447EBI-5849461, EBI-2265428
BINARY P94077DRP3B Q8LFT23EBI-5849461, EBI-2265511
BINARY P94077ERF12 Q94ID63EBI-5849461, EBI-4446727
BINARY P94077GILP Q94CD43EBI-5849461, EBI-6274018
BINARY P94077NFYC8 Q4PSE24EBI-5849461, EBI-15191571
BINARY P94077NFYC9 Q8L4B24EBI-5849461, EBI-2466050
BINARY P94077SRM1 Q9FNN65EBI-5849461, EBI-15195055
BINARY P94077ZIP10 Q8W2453EBI-5849461, EBI-6956003

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region9-39LSD1-type zinc-finger
Region50-80LSD1-type zinc-finger
Region97-127LSD1-type zinc-finger
Region136-159Disordered

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P94077-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    189
  • Mass (Da)
    20,107
  • Last updated
    1997-05-01 v1
  • Checksum
    5EBEE628A30F1550
MKVADMQDQLVCHGCRNLLMYPRGASNVRCALCNTINMVPPPPPPHDMAHIICGGCRTMLMYTRGASSVRCSCCQTTNLVPAHSNQVAHAPSSQVAQINCGHCRTTLMYPYGASSVKCAVCQFVTNVNMSNGRVPLPTNRPNGTACPPSTSTSTPPSQTQTVVVENPMSVDESGKLVSNVVVGVTTDKK

P94077-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-5: Missing

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F4JUW0F4JUW0_ARATHLSD1210
A0A1P8B450A0A1P8B450_ARATHLSD1129

Sequence caution

The sequence BAH57095.1 differs from that shown. Reason: Miscellaneous discrepancy Intron retention.

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0411041-5in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U87833
EMBL· GenBank· DDBJ
AAC49660.1
EMBL· GenBank· DDBJ
mRNA
U87834
EMBL· GenBank· DDBJ
AAC49661.1
EMBL· GenBank· DDBJ
Genomic DNA
AL080253
EMBL· GenBank· DDBJ
CAB45804.1
EMBL· GenBank· DDBJ
Genomic DNA
AL161553
EMBL· GenBank· DDBJ
CAB79038.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84315.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84316.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84317.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84318.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84319.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84320.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE84321.1
EMBL· GenBank· DDBJ
Genomic DNA
AY080824
EMBL· GenBank· DDBJ
AAL87301.1
EMBL· GenBank· DDBJ
mRNA
AY117316
EMBL· GenBank· DDBJ
AAM51391.1
EMBL· GenBank· DDBJ
mRNA
AK318980
EMBL· GenBank· DDBJ
BAH57095.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AY087794
EMBL· GenBank· DDBJ
AAM65330.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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