P93836 · HPPD_ARATH
- Protein4-hydroxyphenylpyruvate dioxygenase
- GeneHPD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids445 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
Catalytic activity
- 3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisateThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Fe cation per subunit.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
11 μM | 4-hydroxyphenylpyruvic acid |
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Cofactor biosynthesis; prenylquinone biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4-hydroxyphenylpyruvate dioxygenase activity | |
Molecular Function | identical protein binding | |
Molecular Function | iron ion binding | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxyphenylpyruvate dioxygenase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP93836
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000088397 | 1-445 | 4-hydroxyphenylpyruvate dioxygenase | |||
Sequence: MGHQNAAVSENQNHDDGAASSPGFKLVGFSKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMVHASYLLTSGDLRFLFTAPYSPSLSAGEIKPTTTASIPSFDHGSCRSFFSSHGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSYKAEDTEKSEFLPGFERVEDASSFPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQFAEFTADDVGTAESGLNSAVLASNDEMVLLPINEPVHGTKRKSQIQTYLEHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMKDEEGKAYQSGGCGGFGKGNFSELFKSIEEYEKTLEAKQLVG |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P93836 | HPD P93836 | 2 | EBI-1251387, EBI-1251387 |
Protein-protein interaction databases
Chemistry
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | ||||
Sequence: MGHQNAAVSENQNHDDGA | ||||||
Region | 1-20 | Disordered | ||||
Sequence: MGHQNAAVSENQNHDDGAAS | ||||||
Domain | 46-192 | VOC 1 | ||||
Sequence: RFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMVHASYLLTSGDLRFLFTAPYSPSLSAGEIKPTTTASIPSFDHGSCRSFFSSHGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSY | ||||||
Domain | 223-383 | VOC 2 | ||||
Sequence: RLDHAVGNVPELGPALTYVAGFTGFHQFAEFTADDVGTAESGLNSAVLASNDEMVLLPINEPVHGTKRKSQIQTYLEHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTK |
Sequence similarities
Belongs to the 4HPPD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
P93836-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length445
- Mass (Da)48,816
- Last updated1998-01-01 v2
- ChecksumFD0442F93556B3F5
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4IDP2 | F4IDP2_ARATH | PDS1 | 418 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | ||||
Sequence: MGHQNAAVSENQNHDDGA |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U89267 EMBL· GenBank· DDBJ | AAB70025.1 EMBL· GenBank· DDBJ | mRNA | ||
AF000228 EMBL· GenBank· DDBJ | AAB58404.1 EMBL· GenBank· DDBJ | mRNA | ||
AF047834 EMBL· GenBank· DDBJ | AAC15697.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007592 EMBL· GenBank· DDBJ | AAF24813.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
CP002684 EMBL· GenBank· DDBJ | AEE28006.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF428446 EMBL· GenBank· DDBJ | AAL16215.1 EMBL· GenBank· DDBJ | mRNA | ||
AY072329 EMBL· GenBank· DDBJ | AAL61936.1 EMBL· GenBank· DDBJ | mRNA | ||
AY128745 EMBL· GenBank· DDBJ | AAM91145.1 EMBL· GenBank· DDBJ | mRNA |