P93836 · HPPD_ARATH

Function

function

Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 1 Fe cation per subunit.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
11 μM4-hydroxyphenylpyruvic acid

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Cofactor biosynthesis; prenylquinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site226Fe cation (UniProtKB | ChEBI)
Binding site308Fe cation (UniProtKB | ChEBI)
Binding site394Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4-hydroxyphenylpyruvate dioxygenase activity
Molecular Functionidentical protein binding
Molecular Functioniron ion binding
Biological ProcessL-phenylalanine catabolic process
Biological Processtyrosine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxyphenylpyruvate dioxygenase
  • EC number
  • Alternative names
    • 4-hydroxyphenylpyruvic acid oxidase (4HPPD; HPD; HPPDase)

Gene names

    • Name
      HPD
    • Synonyms
      PDS1
    • ORF names
      F12K11.9
    • Ordered locus names
      At1g06570

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Wassilewskija
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P93836
  • Secondary accessions
    • F4IDP1
    • O04330
    • Q9SHK1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000883971-4454-hydroxyphenylpyruvate dioxygenase

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P93836HPD P938362EBI-1251387, EBI-1251387

Protein-protein interaction databases

Chemistry

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues
Region1-20Disordered
Domain46-192VOC 1
Domain223-383VOC 2

Sequence similarities

Belongs to the 4HPPD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

P93836-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    445
  • Mass (Da)
    48,816
  • Last updated
    1998-01-01 v2
  • Checksum
    FD0442F93556B3F5
MGHQNAAVSENQNHDDGAASSPGFKLVGFSKFVRKNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMVHASYLLTSGDLRFLFTAPYSPSLSAGEIKPTTTASIPSFDHGSCRSFFSSHGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGDVVLRYVSYKAEDTEKSEFLPGFERVEDASSFPLDYGIRRLDHAVGNVPELGPALTYVAGFTGFHQFAEFTADDVGTAESGLNSAVLASNDEMVLLPINEPVHGTKRKSQIQTYLEHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKKRVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQRVGCMMKDEEGKAYQSGGCGGFGKGNFSELFKSIEEYEKTLEAKQLVG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4IDP2F4IDP2_ARATHPDS1418

Sequence caution

The sequence AAF24813.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-18Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U89267
EMBL· GenBank· DDBJ
AAB70025.1
EMBL· GenBank· DDBJ
mRNA
AF000228
EMBL· GenBank· DDBJ
AAB58404.1
EMBL· GenBank· DDBJ
mRNA
AF047834
EMBL· GenBank· DDBJ
AAC15697.1
EMBL· GenBank· DDBJ
mRNA
AC007592
EMBL· GenBank· DDBJ
AAF24813.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
CP002684
EMBL· GenBank· DDBJ
AEE28006.2
EMBL· GenBank· DDBJ
Genomic DNA
AF428446
EMBL· GenBank· DDBJ
AAL16215.1
EMBL· GenBank· DDBJ
mRNA
AY072329
EMBL· GenBank· DDBJ
AAL61936.1
EMBL· GenBank· DDBJ
mRNA
AY128745
EMBL· GenBank· DDBJ
AAM91145.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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