P93751 · ZFP8_ARATH
- ProteinZinc finger protein 8
- GeneZFP8
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids257 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Probable transcription factor required for the initiation of inflorescence trichomes in response to gibberellin and cytokinin. Is not involved in the regulation of trichome branching. Is functionally equivalent to GIS2 (PubMed:17507408).
Acts as a negative regulator of abscisic acid (ABA) signaling during germination and early seedling development (PubMed:24808098).
Acts as a negative regulator of abscisic acid (ABA) signaling during germination and early seedling development (PubMed:24808098).
Miscellaneous
Seeds over-expressing ZFP8 show decreased sensitivity to inhibition of germination by abscisic acid (ABA).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | abscisic acid-activated signaling pathway | |
Biological Process | cytokinin-activated signaling pathway | |
Biological Process | gibberellic acid mediated signaling pathway | |
Biological Process | negative regulation of abscisic acid-activated signaling pathway | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | trichome differentiation | |
Biological Process | trichome morphogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 8
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP93751
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced trichome production on cauline leaves, stem branches and sepals.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 14 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000425723 | 1-257 | Zinc finger protein 8 | ||
Proteomic databases
Expression
Tissue specificity
Expressed in developing cauline leaves.
Induction
By gibberellin.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P93751 | BBX26 O80748 | 3 | EBI-15193377, EBI-15191535 | |
BINARY | P93751 | TCP13 Q9S7W5 | 3 | EBI-15193377, EBI-4424877 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 48-92 | Disordered | |||
Compositional bias | 62-92 | Basic and acidic residues | |||
Zinc finger | 95-117 | C2H2-type | |||
Region | 108-128 | Disordered | |||
Region | 214-238 | Disordered | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length257
- Mass (Da)29,571
- Last updated1997-05-01 v1
- MD5 Checksum84B7503E194D5DAD1E596AD62D7B1508
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 62-92 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L39651 EMBL· GenBank· DDBJ | AAA87304.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
U90439 EMBL· GenBank· DDBJ | AAB63548.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC10051.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY039597 EMBL· GenBank· DDBJ | AAK62652.1 EMBL· GenBank· DDBJ | mRNA | ||
AY056093 EMBL· GenBank· DDBJ | AAL06981.1 EMBL· GenBank· DDBJ | mRNA |