P93313 · NU4M_ARATH

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated gene (At2g07717) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentplastid
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular Functionubiquinone binding
Biological Processaerobic respiration
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 4

Gene names

    • Name
      ND4
    • Synonyms
      NAD4
    • Ordered locus names
      AtMg00580

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • cv. C24
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P93313
  • Secondary accessions
    • A0A2P2CLG4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-29Helical
Transmembrane39-59Helical
Transmembrane89-109Helical
Transmembrane118-138Helical
Transmembrane173-193Helical
Transmembrane214-234Helical
Transmembrane245-265Helical
Transmembrane272-292Helical
Transmembrane335-355Helical
Transmembrane367-387Helical
Transmembrane413-433Helical
Transmembrane457-477Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001178891-495NADH-ubiquinone oxidoreductase chain 4

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Complex I is composed of at least 49 different subunits.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    495
  • Mass (Da)
    55,942
  • Last updated
    2023-09-13 v3
  • Checksum
    7B70B7EB8BF5EC6B
MLEHFCECYFNLSGLILCPVLGSIILLFIPNSRIRLIRLIGLCASLITFLYSLVLWIQFDSSTAKFQFVESLRWLPYENINFYLGIDGISLFFVILTTFLIPICILVGWSGMRSYGKEYIIAFLICEFLMIAVFCMLDLLLFYVFFESVLIPMFIIIGVWGSRQRKIKAAYQFFLYTLLGSLFMLLAILLILFQTGTTDLQILLTTEFSERRQIFLWIAFFASFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGILLKFGTYGFLRFSIPMFPEATLCFTPFIYTLSAIAIIYTSLTTLRQIDLKKIIAYSSVAHMNLVTIGMFSLNIQGIGGSILLMLSHGLVSSALFLCVGVLYDRHKTRLVRYYGGLVSTMPNFSTIFFFFTLANMSLPGTSSFIGEFLILVGAFQRNSLVATLAALGMILGAAYSLWLYNRVVSGNLKPDFLHKFSDLNGREVFIFIPFLVGVVWMGVYPKVFLDCMHTSVSNLVQHGKFH

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict146in Ref. 1; CAA69742
Sequence conflict326in Ref. 1; CAA69742
Sequence conflict383in Ref. 1; CAA69742
Sequence conflict467in Ref. 1; CAA69742

RNA Editing

Edited at positions 10
25
36
53
55
56
66
106
121
126
135
150
203
220
256
262
279
299
337
345
377
391
452
458
469
473
478

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y08501
EMBL· GenBank· DDBJ
CAA69742.3
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BK010421
EMBL· GenBank· DDBJ
DAB41509.2
EMBL· GenBank· DDBJ
Genomic DNA
AC007729
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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