P92558 · NU1M_ARATH
- ProteinNADH-ubiquinone oxidoreductase chain 1
- GeneND1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids325 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Miscellaneous
A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated genes (At2g07785 and At2g07786) is not demonstrated. They are also probably not RNA edited and therefore differs in all the positions known to be edited.
Catalytic activity
- a ubiquinone + 5 H+(in) + NADH = a ubiquinol + 4 H+(out) + NAD+
a ubiquinone RHEA-COMP:9565 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = a ubiquinol RHEA-COMP:9566 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | aerobic respiration |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 1
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP92558
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 5-25 | Helical | ||||
Sequence: VPAEILGIILPLLLGVAFLVL | ||||||
Transmembrane | 68-88 | Helical | ||||
Sequence: SANFFLFRMAPVATFMLSLVA | ||||||
Transmembrane | 105-125 | Helical | ||||
Sequence: IGLLYLFAISSLGVYGIIIAG | ||||||
Transmembrane | 144-164 | Helical | ||||
Sequence: MVSYEVSIGLILITVLICVGS | ||||||
Transmembrane | 177-197 | Helical | ||||
Sequence: IWFGIPLFPVLVMFFISCLAE | ||||||
Transmembrane | 227-247 | Helical | ||||
Sequence: LFFLGEYANMILMSGLCTLFF | ||||||
Transmembrane | 263-283 | Helical | ||||
Sequence: IPGSIWFSIKVLFFLFLYIWV | ||||||
Transmembrane | 302-322 | Helical | ||||
Sequence: VFLPLSLARVVPVSGLLVTFQ |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000117344 | 1-325 | NADH-ubiquinone oxidoreductase chain 1 | |||
Sequence: MYIAVPAEILGIILPLLLGVAFLVLAERKVMAFVQRRKGPDVVGSFGLLQPLADGLKLILKEPISPSSANFFLFRMAPVATFMLSLVAWAVVPFDYGMVLSDLNIGLLYLFAISSLGVYGIIIAGWSSISKYAFLGALRSAAQMVSYEVSIGLILITVLICVGSCNLSEIVMAQKQIWFGIPLFPVLVMFFISCLAETNRAPFDLPEAEAELVAGYNVEYSSMGFALFFLGEYANMILMSGLCTLFFLGGWLPILDLPIFKKIPGSIWFSIKVLFFLFLYIWVRAAFPRYRYDQLMGLGWKVFLPLSLARVVPVSGLLVTFQWLP |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Sequence similarities
Belongs to the complex I subunit 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)36,009
- Last updated2023-09-13 v5
- Checksum9659CCF300B7F926
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q3EC42 | Q3EC42_ARATH | At2g07785 | 99 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 129 | in Ref. 1; CAA57940 | ||||
Sequence: I → N |
RNA Editing
Edited at positions 1 56 89 103 126 164 165 167 179 191 194 212 225 242 248 252 275 300 310 313
The initiator methionine is created by RNA editing
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X82618 EMBL· GenBank· DDBJ | CAA57940.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
Y08501 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK010421 EMBL· GenBank· DDBJ | DAB41492.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007729 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002685 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |