P91927 · LETM1_DROME

Function

function

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion.

Features

Showing features for binding site.

110131002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site700Ca2+ 1 (UniProtKB | ChEBI)
Binding site702Ca2+ 1 (UniProtKB | ChEBI)
Binding site704Ca2+ 1 (UniProtKB | ChEBI)
Binding site711Ca2+ 1 (UniProtKB | ChEBI)
Binding site783Ca2+ 2 (UniProtKB | ChEBI)
Binding site785Ca2+ 2 (UniProtKB | ChEBI)
Binding site787Ca2+ 2 (UniProtKB | ChEBI)
Binding site794Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial membrane
Cellular Componentmitochondrion
Cellular Componentpresynapse
Molecular Functioncalcium ion binding
Molecular Functioncalcium:sodium antiporter activity
Molecular Functionpotassium:proton antiporter activity
Molecular Functionribosome binding
Biological Processcellular response to hypoxia
Biological Processintracellular monoatomic cation homeostasis
Biological Processmitochondrial calcium ion transmembrane transport
Biological Processmitochondrion organization
Biological Processneurotransmitter secretion
Biological Processpotassium ion transmembrane transport
Biological Processproton transmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 2.A.97.1.3the mitochondrial inner membrane k+/h+ and ca2+/h+ exchanger (letm1) family

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial proton/calcium exchanger protein
  • Alternative names
    • Leucine zipper-EF-hand-containing transmembrane protein 1 (dLetm1
      )

Gene names

    • Name
      Letm1
    • Synonyms
      anon-60Da
    • ORF names
      CG4589

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P91927
  • Secondary accessions
    • A4UZV1
    • Q0E8W7
    • Q9W160

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane237-257Helical

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-60Mitochondrion
ChainPRO_000007386161-1013Mitochondrial proton/calcium exchanger protein

Proteomic databases

Expression

Gene expression databases

    • FBgn0284252Expressed in adult hindgut (Drosophila) and 34 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, domain, compositional bias, region.

TypeIDPosition(s)Description
Coiled coil104-131
Domain280-554Letm1 RBD
Coiled coil488-525
Coiled coil573-653
Domain687-722EF-hand 1
Domain770-805EF-hand 2
Coiled coil823-919
Compositional bias877-925Basic and acidic residues
Region877-1004Disordered
Compositional bias926-962Polar residues
Compositional bias979-1004Polar residues

Sequence similarities

Belongs to the LETM1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,013
  • Mass (Da)
    113,580
  • Last updated
    2001-02-21 v2
  • Checksum
    8C710380263F262E
MNALLRHKGRNLRTSHLAQNVYKRFLKSNCCACSSVNVTDEPAKEDELPRRSASTSVLELSRSLGTYRRFQPHANYGYDYSGYGFRHLHTSRTLLETSSSKIDATVKKLKNQQKEKVEEIMKEVANGQAAAVRASSAATATASSEKGQNASATAGSTSATASTTSLAKTADKSVAKPKKPLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHKEHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAHTRHAIGESEGKVDNKTKIEIIKEEERKIREEREEEREETIAKRSAIKEEIPAPYVFAEKLSGSQDLLDHKEQSSVSETDKGISSTDVQLLSEALKTLSSDKQLVVEKETIKELKEELADYKEDVEELREVRQVVKEPVRESRAAKLLYNRVNKMISQLDNVLNDLEARQHQIKQAESSDYAASSPTVEPQQMVHIDELVATIRRMKEASDEERFKVVGDLLVKLDADKDGVISVNEITKAVQSIDREATNIDKKQLEEFTELLSKLASRRRHEEIVHIDDLMNNIKVLKETSDEARLKHIEAVLEKFDADKDGVVTVNDIRKVLESIGRDNIKLSDKAIEELISLLDKEQVLQAEQKIEKAIAKSMKEAEKLKSEVDKADKDLSKLVNDIHDSAKEIQDIANEMRDKEETVPDKAKELKAEPAFKDTAKTLKDNAKDLDDLAKDPKSDPKSPTKASTGSGPAGLSGGGPSSGSSGIATGSTTESALREAAERQMEKILPSTDIGLPPTIQTPSQPPTSKKATATASTLSTTITAKKLL

Sequence caution

The sequence CAA71853.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict687in Ref. 4; CAA71853
Sequence conflict690in Ref. 4; CAA71853
Sequence conflict717in Ref. 4; CAA71853
Sequence conflict736in Ref. 4; CAA71853
Sequence conflict740in Ref. 4; CAA71853
Sequence conflict761in Ref. 4; CAA71853
Compositional bias877-925Basic and acidic residues
Compositional bias926-962Polar residues
Sequence conflict943in Ref. 4; CAA71853
Compositional bias979-1004Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013599
EMBL· GenBank· DDBJ
AAM68316.1
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
AAM68317.1
EMBL· GenBank· DDBJ
Genomic DNA
AY047527
EMBL· GenBank· DDBJ
AAK77259.1
EMBL· GenBank· DDBJ
mRNA
Y10912
EMBL· GenBank· DDBJ
CAA71853.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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