P91124 · RIC19_CAEEL

  • Protein
    Resistance to inhibitors of cholinesterase protein 19
  • Gene
    ric-19
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in neurotransmitter secretion (PubMed:11029035).
In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons (PubMed:22654674).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic vesicle membrane
Cellular ComponentGolgi apparatus
Molecular Functionprotein domain specific binding
Molecular Functionsmall GTPase binding
Biological Processdense core granule maturation
Biological Processneurotransmitter transport
Biological Processregulation of locomotion involved in locomotory behavior
Biological Processregulation of neurotransmitter secretion
Biological Processregulation of transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Resistance to inhibitors of cholinesterase protein 19
  • Alternative names
    • ICA1 homolog

Gene names

    • Name
      ric-19
    • ORF names
      C32E8.7

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P91124

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Cytoplasmic vesicle membrane
; Peripheral membrane protein
Note: Co-localizes with tbc-8 at cytoplasmic vesicle membranes in neurons.

Keywords

Phenotypes & Variants

Disruption phenotype

Mutants are resistant to aldicarb, an inhibitor of acetylcholinesterase.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000973311-430Resistance to inhibitors of cholinesterase protein 19

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in all neurons (PubMed:11029035, PubMed:22654674).
Highly expressed in m2 pharyngeal neurons and some pharyngeal interneurons (PubMed:11029035).
Also expressed in the excretory canal and the gland cells located just below the nerve ring in the head (PubMed:11029035).

Gene expression databases

    • WBGene00004368Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

Interacts with the GTPase activator protein tbc-8; the interaction is direct and may be required for the activation of rab-2 and dense vesicle maturation in cholinergic motoneurons (PubMed:22654674).
Interacts with rund-1 (PubMed:24698274).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain56-260AH
Compositional bias279-310Basic and acidic residues
Region279-342Disordered
Compositional bias318-342Basic and acidic residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    430
  • Mass (Da)
    48,906
  • Last updated
    2006-05-30 v2
  • Checksum
    E238258E3389349A
MAAQFYERNTSGMNADRFMTRLTDESTVNTMQRHYWTARQFIRTKLGKKEDEHLEASDNELDTCLNLYRSVHGTSFQLLNNVDNYANFLLDETLVQNVLGKYLKEKGKIDKTEAVGRILIAVGRSLLFSSHRLNAARIGVSTFYNKLSVFVERAIGDCSQTIEAVQMCRTEYRGSLLWMKKTSEELDPEVDGSMEKFREAQTTVKSNKERLDRLKTDTLQKVDLLSASRSNLLSYVLTHYQNELYEYYSKTSRAFETLAENINCYNNYDFEILSHLATGTKPERERKSEKEESAKTSQPRGNEEELKNLLFGRESPQFGEEEVQDESRSQCDSPLIEDVDDERRKTGDLLDLESAASIAFPIGPLATLFDTSSFVPPILPPPKPNAVSDDILSLFDGNKANSSGKEASATTMDWQSLIDGFDRENEDNLL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias279-310Basic and acidic residues
Compositional bias318-342Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284601
EMBL· GenBank· DDBJ
CCD66406.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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