P90978 · U2AF2_CAEEL

  • Protein
    Splicing factor U2AF 65 kDa subunit
  • Gene
    uaf-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcommitment complex
Cellular Componentnuclear speck
Cellular Componentnucleoplasm
Cellular Componentspliceosomal complex
Cellular ComponentU2-type prespliceosome
Cellular ComponentU2AF complex
Molecular Functionpoly-pyrimidine tract binding
Molecular Functionpre-mRNA 3'-splice site binding
Biological Processdevelopmental growth
Biological Processembryo development ending in birth or egg hatching
Biological Processembryonic body morphogenesis
Biological Processgerm cell development
Biological ProcessmRNA 3'-splice site recognition
Biological Processnematode larval development
Biological Processregulation of mRNA splicing, via spliceosome
Biological Processspliceosomal complex assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Splicing factor U2AF 65 kDa subunit
  • Alternative names
    • U2 auxiliary factor 65 kDa subunit (U2AF65)
    • U2 snRNP auxiliary factor large subunit

Gene names

    • Name
      uaf-1
    • ORF names
      Y92C3B.2

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    P90978
  • Secondary accessions
    • O76839
    • Q95XT0
    • Q9N2X5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000819911-496Splicing factor U2AF 65 kDa subunit

Proteomic databases

PTM databases

Expression

Gene expression databases

    • WBGene00006697Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Forms a heterodimer with the U2AF small subunit.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-21Basic and acidic residues
Region1-142Disordered
Compositional bias72-138Basic and acidic residues
Domain184-266RRM 1
Domain291-368RRM 2
Domain404-488RRM 3

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing. Experimental confirmation may be lacking for some isoforms.

P90978-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    496
  • Mass (Da)
    55,431
  • Last updated
    2000-05-30 v2
  • Checksum
    1A967DE89DC9373C
MSDHQDGMKLEDIERQFLDVAQREGGLEAIQPTTGPLENEENLKSSTGGGGGEDDNDRKKRKRSRSRDRDTRRRSRSRDRGERRGGGGGGDRDRSRSRERRRGGGGRDEPRRRGGDDEARSRREPEPQKPREPKKYRFWDVPPTGFETTTPMEYKNMQAAGQVPRGSVQSAVPVVGPSVTCQSRRLYVGNIPFGCNEEAMLDFFNQQMHLCGLAQAPGNPILLCQINLDKNFAFIEFRSIDETTAGMAFDGINFMGQQLKVRRPRDYQPSQNTFDMNSRMPVSTIVVDSANKIFIGGLPNYLTEDQVKELLCSFGPLKAFSLNVDSQGNSKGYAFAEYLDPTLTDQAIAGLNGMQLGDKQLVVQLACANQQRHNTNLPNSASAIAGIDLSQGAGRATEILCLMNMVTEDELKADDEYEEILEDVRDECSKYGIVRSLEIPRPYEDHPVPGVGKVFVEFASTSDCQRAQAALTGRKFANRTVVTSYYDVDKYHNRQF

P90978-2

  • Name
    B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P90978-3

  • Name
    C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-21Basic and acidic residues
Alternative sequenceVSP_0059041-353in isoform B
Alternative sequenceVSP_00590557-78in isoform C
Compositional bias72-138Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U79157
EMBL· GenBank· DDBJ
AAC26982.1
EMBL· GenBank· DDBJ
mRNA
FO080242
EMBL· GenBank· DDBJ
CCD62278.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080242
EMBL· GenBank· DDBJ
CCD62279.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080242
EMBL· GenBank· DDBJ
CCD62280.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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