P90680 · OPSB_APIME
- ProteinOpsin, blue-sensitive
- GeneBLOP
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids377 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to 11-cis-retinal.
Absorption
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | G protein-coupled photoreceptor activity | |
Biological Process | cellular response to light stimulus | |
Biological Process | detection of light stimulus involved in visual perception | |
Biological Process | phototransduction |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameOpsin, blue-sensitive
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis
Accessions
- Primary accessionP90680
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-56 | Extracellular | ||||
Sequence: MLLHNKTLAGKALAFIAEEGYVPSMREKFLGWNVPPEYSDLVHPHWRAFPAPGKHF | ||||||
Transmembrane | 57-81 | Helical; Name=1 | ||||
Sequence: HIGLAIIYSMLLIMSLVGNCCVIWI | ||||||
Topological domain | 82-93 | Cytoplasmic | ||||
Sequence: FSTSKSLRTPSN | ||||||
Transmembrane | 94-119 | Helical; Name=2 | ||||
Sequence: MFIVSLAIFDIIMAFEMPMLVISSFM | ||||||
Topological domain | 120-132 | Extracellular | ||||
Sequence: ERMIGWEIGCDVY | ||||||
Transmembrane | 133-152 | Helical; Name=3 | ||||
Sequence: SVFGSISGMGQAMTNAAIAF | ||||||
Topological domain | 153-170 | Cytoplasmic | ||||
Sequence: DRYRTISCPIDGRLNSKQ | ||||||
Transmembrane | 171-195 | Helical; Name=4 | ||||
Sequence: AAVIIAFTWFWVTPFTVLPLLKVWG | ||||||
Topological domain | 196-219 | Extracellular | ||||
Sequence: RYTTEGFLTTCSFDFLTDDEDTKV | ||||||
Transmembrane | 220-247 | Helical; Name=5 | ||||
Sequence: FVTCIFIWAYVIPLIFIILFYSRLLSSI | ||||||
Topological domain | 248-282 | Cytoplasmic | ||||
Sequence: RNHEKMLREQAKKMNVKSLVSNQDKERSAEVRIAK | ||||||
Transmembrane | 283-306 | Helical; Name=6 | ||||
Sequence: VAFTIFFLFLLAWTPYATVALIGV | ||||||
Topological domain | 307-314 | Extracellular | ||||
Sequence: YGNRELLT | ||||||
Transmembrane | 315-339 | Helical; Name=7 | ||||
Sequence: PVSTMLPAVFAKTVSCIDPWIYAIN | ||||||
Topological domain | 340-377 | Cytoplasmic | ||||
Sequence: HPRYRQELQKRCKWMGIHEPETTSDATSAQTEKIKTDE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000197638 | 1-377 | Opsin, blue-sensitive | |||
Sequence: MLLHNKTLAGKALAFIAEEGYVPSMREKFLGWNVPPEYSDLVHPHWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFSTSKSLRTPSNMFIVSLAIFDIIMAFEMPMLVISSFMERMIGWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYRTISCPIDGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTTEGFLTTCSFDFLTDDEDTKVFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHEKMLREQAKKMNVKSLVSNQDKERSAEVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNRELLTPVSTMLPAVFAKTVSCIDPWIYAINHPRYRQELQKRCKWMGIHEPETTSDATSAQTEKIKTDE | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 129↔206 | |||||
Sequence: CDVYSVFGSISGMGQAMTNAAIAFDRYRTISCPIDGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTTEGFLTTC | ||||||
Modified residue | 326 | N6-(retinylidene)lysine | ||||
Sequence: K |
Post-translational modification
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the dorsal region of the retina and sparsely expressed in the ventral region.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length377
- Mass (Da)42,997
- Last updated2008-11-25 v2
- Checksum5329E0593C3492E6
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 43 | in Ref. 1; AAC47455 | ||||
Sequence: H → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U70841 EMBL· GenBank· DDBJ | AAC47455.1 EMBL· GenBank· DDBJ | mRNA | ||
AF004168 EMBL· GenBank· DDBJ | AAC13417.1 EMBL· GenBank· DDBJ | mRNA | ||
AADG06002981 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK005512 EMBL· GenBank· DDBJ | DAA05737.1 EMBL· GenBank· DDBJ | Genomic DNA |