P87558 · NP_ADECT

Function

function

Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Also plays a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Features

Showing features for site.

1134102030405060708090100110120130
TypeIDPosition(s)Description
Site23-24Cleavage; by viral protease

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleolus
Cellular Componentviral capsid
Molecular FunctionDNA binding
Biological Processsymbiont entry into host cell
Biological Processviral penetration into host nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-histone-like nucleoprotein
  • Alternative names
    • Pre-core protein VII
      (pVII
      )
  • Cleaved into 1 chains

Gene names

    • Name
      L2

Organism names

Accessions

  • Primary accession
    P87558

Subcellular Location

Histone-like nucleoprotein

Virion
Note: Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.

Pre-histone-like nucleoprotein

Host nucleus, host nucleolus

Keywords

PTM/Processing

Features

Showing features for initiator methionine, propeptide, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
PropeptidePRO_00004398442-23
ChainPRO_00004398432-134Pre-histone-like nucleoprotein
ChainPRO_000003659224-134Histone-like nucleoprotein

Post-translational modification

Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region40-62Disordered
Motif125-134Nuclear localization signal

Sequence similarities

Belongs to the adenoviridae histone-like nucleoprotein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    134
  • Mass (Da)
    15,085
  • Last updated
    1998-12-15 v2
  • Checksum
    B70C8CA17A2B13C9
MAILISPTNNTGWGLGTHKLFGGAKQKSDQHPVYVQAHYRASWGSKGRRRRQGRARGAPLDPKTEAEMVATIDEVARNGPPAARLVLEAARRVGAYNLRRARKLTPAGRAMMAMRARQMVKQAKKRKRRVRFRQ

Sequence caution

The sequence AAB38721.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence AAB38721.1 differs from that shown. Reason: Erroneous initiation

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U77082
EMBL· GenBank· DDBJ
AAB38721.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Similar Proteins

Disclaimer

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