P87557 · P87557_ADECT

Function

function

Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein, and in endocytosis of virions. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Cellular ComponentT=25 icosahedral viral capsid
Molecular Functionstructural molecule activity
Biological Processendocytosis involved in viral entry into host cell
Biological Processvirion attachment to host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Penton protein
  • Short names
    CP-P
  • Alternative names
    • Penton base protein
    • Protein III

Gene names

    • Name
      L2

Organism names

Accessions

  • Primary accession
    P87557

Proteomes

Subcellular Location

Virion
Host nucleus
Note: Located at each vertex of the virion.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with the fiber protein (via N-terminal tail region). Interacts with the capsid vertex protein; this interaction binds the penton base to neighboring peripentonal hexons.

Family & Domains

Sequence similarities

Belongs to the adenoviridae penton family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    53,563
  • Last updated
    1997-05-01 v1
  • Checksum
    E1121047D541BDF7
MEFSSSPPPSYETVMAQVPSILAPLVPPRYKGATEGRNSIRYSQLPPLFDTTKLYLIDNKSSDIQALNYQNDHSNFLTTVVQNANYTPMEASTQSIQLDERSRWGGEFKSILHMNMPNVTEYMFSNSFKAYLPATADNFGKVLTYEWYTLTIPEGNYSEVMLLDLLNNAVVENYLAHGRQHNVREEDMGLKFDTRNFHLGFDPETKLVMPGFYTNEAFHPDIVLSPGCAVDFTHSRLNNFLGIRKRLPYQEGFVITWEDLQGGNIPALLDLENYNPDIPGADITPLMYDSKGRPYHVGEDPSAGSTFTWYRSWFVAYNYGPADGIKSKTVLVAPDITCGVEQIYWSLPDMAVDPVTFTSSHNPSSYPVVGTELLPLLPRSFYNGSSVYSQLLQESTSQTQVFNRFPENAILKRPPAPTIISISENVPALSNHGTLPLKNNIPGVQRVTITDARRRVCPYVYKSLGVVVPRALSSKTF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U77082
EMBL· GenBank· DDBJ
AAB38720.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp