P87553 · DPOL_ADECT

Function

function

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Miscellaneous

This DNA polymerase requires a protein as a primer.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular Function3'-5' exonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionnucleotide binding
Biological ProcessDNA-templated DNA replication
Biological Processviral DNA genome replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase
  • EC number

Gene names

    • Name
      POL

Organism names

Accessions

  • Primary accession
    P87553

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000464991-1150DNA polymerase

Interaction

Subunit

Heterodimer with the terminal protein; this heterodimer binds to bp 9 to 18 of the genome. Forms a complex with viral pTP, DBP and hosts NFIA and POU2F1/OCT1 for initiation of replication.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-49Polar residues
Region1-53Disordered

Sequence similarities

Belongs to the DNA polymerase type-B family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,150
  • Mass (Da)
    130,460
  • Last updated
    1997-05-01 v1
  • Checksum
    474E0F53705C5873
MSLVQGHGTSGLFTEPPNPINQQESSGPSLPAQDAAQAFASSPRAGATSTIVNPPKRKYKGAVVVQRATLSISAVLDNGQCVEIKYHSNLASALTNLCNTNLYDLPACLNRPITAHNLPALIEEAAAPYSLICYYQRGTVRRVEFQAEVPLLSFPLKFLVKQGKVFLIKDISQMQKCEFCGSFFKVTHTCALRRRDFYFHHVAAHSADWWEKISFTPIGAPPNTERLFIVYDVETYTWHGKFGKQLVPFMLVFQLLGDDHLVNVAKTLATEQNWEIWNGKEQDTLYYCITPEKRAIGVKFKKFRDTLQQHIAASLWSHVICQNPQLQEKATTLGLESPEELTPDQLKKFKLKGNPRFIEVYAVGHNITGFDEILLAAQVVSTRAEIPPVFEICRNFMPRAGRLLFNDITYSLPNPSYVPAKSYEHWEQGQVLASDLKSQYIKFMVRDTFSLTHTSLKNAAKAYSLTVSKGCCPYQAVNEFYMLGSYQQDADGFPDLKYWKDQEEYSFNKDLWIKEKKGAYDIIQQTLDYCALDVQVTAQLVNKLIESYQIFIKNSVNLPETSFNVFQRPTISSNSHAIFKQILYKAEKPNTHHLSTILMAPSNEMYEYVRLSIRGGRCYPTYIGVLQEPVFVYDICGMYASALTHPFPAGSPLNPYERALAIKAYEQKMLNHKTISYFDKDLLPGIFTIDADPPAEEFLDVLPPFCSRKGGRLCWTNEPLRGEIATSIDVITLHNRGWKVTLIPDTRTTVFPEWKCLAREYVQLNISAKEEADKSKNQTMRSIAKLLSNALYGSFATKLDNKKTVFSDQIESNIAKEIASGAYVVKSSSYIETDNLCAEIMPEFVVAYPPVNSDVRQLAPPSCSEEDPTKDPLAEAPFMHNFSMTSYHYKPIMFIDAEDDDFCLHTLEKSTPLIANNRYPSQIASFVLAWTRAFVSEWSQFLYENDAGTPLENRVLKSVYGDTDSLFTTMEGYKLMEEKGKKRLKKNGGKLVFDPSNPELTWLVECETQCEKCGSDAYSSESVYLAPKLYALKDTTCPKCHHVGKGKLRAKGHATSTLSYDVLKACYYADMQQGSDVFKTSRMSLRRTLTSVQAHVQPFTVTETTLTRKLRPWKDKTLHALDMHRLIPYSRKHPNPRNTETTWMELQWMT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-49Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U77082
EMBL· GenBank· DDBJ
AAB38716.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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