P86934 · EF1A1_TRYB2
- ProteinElongation factor 1-alpha 1
- GeneTEF1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids449 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Miscellaneous
The Kennedy pathway is the major route for phosphatidylethanolamine (PE) synthesis, as shown by reduced levels after using RNAi against the first two enzymes of the Kennedy pathway.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | calmodulin binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | mRNA binding | |
Molecular Function | translation elongation factor activity | |
Biological Process | calcium-mediated signaling | |
Biological Process | microtubule-based process | |
Biological Process | translation | |
Biological Process | translational elongation |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameElongation factor 1-alpha 1
- Short namesEF-1-alpha 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma
Accessions
- Primary accessionP86934
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000412120 | 1-449 | Elongation factor 1-alpha 1 | |||
Sequence: MGKEKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAADIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILIIASAQGEFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVNYGQERYDEIVKEVSAYIKKVGYNVEKVRFVPISGWQGDNMIEKSEKMPWYKGPTLLEALDMLEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVMKPGDVVTFAPANVTTEVKSIEMHHEQLAEATPGDNVGFNVKNVSVKDIRRGNVCGNTKNDPPKEAADFTAQVIILNHPGQIGNGYAPVLDCHTSHIACKFAEIESKIDRRSGKELEKAPKSIKSGDAAIVRMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKAVTKKDGSGGKVTKAAVKASKK | ||||||
Modified residue | 362 | 5-glutamyl glycerylphosphorylethanolamine | ||||
Sequence: E |
Post-translational modification
Phosphatidylethanolamine (PE) is a direct precursor of the ethanolamine-phosphoglycerol (EPG) moiety.
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-230 | tr-type G | ||||
Sequence: KVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAADIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILIIASAQGEFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVNYGQERYDEIVKEVSAYIKKVGYNVEKVRFVPISGWQGDNMIEKSEKMPWYKGPTLLEALDMLEPPVRPS | ||||||
Region | 14-21 | G1 | ||||
Sequence: GHVDAGKS | ||||||
Region | 70-74 | G2 | ||||
Sequence: GITID | ||||||
Region | 91-94 | G3 | ||||
Sequence: DAPG | ||||||
Region | 153-156 | G4 | ||||
Sequence: NKMD | ||||||
Region | 194-196 | G5 | ||||
Sequence: SGW |
Sequence similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length449
- Mass (Da)49,106
- Last updated2011-07-27 v1
- ChecksumD597D39CE436660D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM000208 EMBL· GenBank· DDBJ | EAN77638.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L25868 EMBL· GenBank· DDBJ | AAA16602.1 EMBL· GenBank· DDBJ | Unassigned DNA |