P86881 · NGB_DISMA
- ProteinNeuroglobin
- Genengb
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids159 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide. Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress.
Catalytic activity
- Fe(III)-heme b-[protein] + H2O + nitric oxide = Fe(II)-heme b-[protein] + 2 H+ + nitriteThis reaction proceeds in the backward direction.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial matrix | |
Molecular Function | GDP-dissociation inhibitor activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | nitrite reductase activity | |
Molecular Function | oxygen binding | |
Biological Process | cellular response to hypoxia |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNeuroglobin
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Nototheniidae > Dissostichus
Accessions
- Primary accessionP86881
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Note: Enriched in mitochondrial matrix upon oxygen-glucose deprivation.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000419966 | 1-159 | Neuroglobin | |||
Sequence: MEKLSEKDKELIRGSWESLGKNKVPHGVVMFSRLFELDPELLTLFHYTTNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSNLDDLPSLEDFLLNLGRKHQAVGVNTQSFAEVGESLLHMLQCSLGQAYTAPLRQAWLNLYSIVVAAMSQGWAKNGEDKAD |
Interaction
Subunit
Monomer (By similarity).
Homodimers and homotetramers. Mainly monomeric but also detected as part of homodimers and homotetramers (By similarity).
Homodimers and homotetramers. Mainly monomeric but also detected as part of homodimers and homotetramers (By similarity).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-151 | Globin | ||||
Sequence: KLSEKDKELIRGSWESLGKNKVPHGVVMFSRLFELDPELLTLFHYTTNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSNLDDLPSLEDFLLNLGRKHQAVGVNTQSFAEVGESLLHMLQCSLGQAYTAPLRQAWLNLYSIVVAAMSQGWA |
Sequence similarities
Belongs to the globin family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length159
- Mass (Da)17,669
- Last updated2012-10-31 v1
- Checksum70E696FC1C10A98E