P86881 · NGB_DISMA

Function

function

Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide. Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress.

Catalytic activity

Features

Showing features for binding site.

115920406080100120140
TypeIDPosition(s)Description
Binding site66Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); distal binding residue; reversible
Binding site98Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial matrix
Molecular FunctionGDP-dissociation inhibitor activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionnitrite reductase activity
Molecular Functionoxygen binding
Biological Processcellular response to hypoxia

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuroglobin
  • Alternative names
    • Nitrite reductase
      (EC:1.7.-.-
      ) . EC:1.7.-.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      ngb

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Nototheniidae > Dissostichus

Accessions

  • Primary accession
    P86881
  • Secondary accessions
    • D2EA91

Subcellular Location

Cytoplasm, cytosol
Mitochondrion matrix
Note: Enriched in mitochondrial matrix upon oxygen-glucose deprivation.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004199661-159Neuroglobin

Interaction

Subunit

Monomer (By similarity).
Homodimers and homotetramers. Mainly monomeric but also detected as part of homodimers and homotetramers (By similarity).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-151Globin

Sequence similarities

Belongs to the globin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    17,669
  • Last updated
    2012-10-31 v1
  • Checksum
    70E696FC1C10A98E
MEKLSEKDKELIRGSWESLGKNKVPHGVVMFSRLFELDPELLTLFHYTTNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSNLDDLPSLEDFLLNLGRKHQAVGVNTQSFAEVGESLLHMLQCSLGQAYTAPLRQAWLNLYSIVVAAMSQGWAKNGEDKAD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM204871
EMBL· GenBank· DDBJ
CAR57911.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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