P86775 · PRVB2_MERPR
- ProteinParvalbumin beta 2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids108 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).
Miscellaneous
Is regarded as an important allergen.
On the 2D-gel the determined pI of this protein is: 4.29, its MW is: 11.50 kDa.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 51 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 53 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 55 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 57 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 59 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 62 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 90 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 92 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 94 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 96 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 101 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameParvalbumin beta 2
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Zeiogadaria > Gadariae > Gadiformes > Gadoidei > Merlucciidae > Merluccius
Accessions
- Primary accessionP86775
Phenotypes & Variants
Keywords
- Disease
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000399435 | 1-108 | Parvalbumin beta 2 | |||
Sequence: AFSGILAEADIAAALKACAAADTFNYKAFFAKVGLSAKSADDIKKAFFVIDQDKSGFIEEDELKLFLQVFSAGARALTDAETKAFLKAGDSDGDGAIGVDEFAVLVKA |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 38-73 | EF-hand 1 | ||||
Sequence: KSADDIKKAFFVIDQDKSGFIEEDELKLFLQVFSAG | ||||||
Domain | 77-108 | EF-hand 2 | ||||
Sequence: LTDAETKAFLKAGDSDGDGAIGVDEFAVLVKA |
Sequence similarities
Belongs to the parvalbumin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length108
- Mass (Da)11,276
- Last updated2010-10-05 v1
- ChecksumABD1ED1F6F1B00A2
Features
Showing features for sequence uncertainty.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence uncertainty | 5 | I or L | ||||
Sequence: I | ||||||
Sequence uncertainty | 6 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 11 | I or L | ||||
Sequence: I | ||||||
Sequence uncertainty | 15 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 16 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 27 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 32 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 35 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 38 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 43 | I or L | ||||
Sequence: I | ||||||
Sequence uncertainty | 44 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 45 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 50 | I or L | ||||
Sequence: I | ||||||
Sequence uncertainty | 52 | Q or K | ||||
Sequence: Q | ||||||
Sequence uncertainty | 54 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 58 | I or L | ||||
Sequence: I | ||||||
Sequence uncertainty | 63 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 64 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 65 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 67 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 68 | Q or K | ||||
Sequence: Q | ||||||
Sequence uncertainty | 77 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 83 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 86 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 87 | K or Q | ||||
Sequence: K | ||||||
Sequence uncertainty | 97 | I or L | ||||
Sequence: I | ||||||
Sequence uncertainty | 105 | L or I | ||||
Sequence: L | ||||||
Sequence uncertainty | 107 | K or Q | ||||
Sequence: K |
Mass Spectrometry
Keywords
- Technical term