P86757 · PRVB2_MERCP

Function

function

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).

Miscellaneous

Is regarded as an important allergen.
On the 2D-gel the determined pI of this protein is: 4.20, its MW is: 11.38 kDa.

Features

Showing features for binding site.

1108102030405060708090100
TypeIDPosition(s)Description
Binding site51Ca2+ 1 (UniProtKB | ChEBI)
Binding site53Ca2+ 1 (UniProtKB | ChEBI)
Binding site55Ca2+ 1 (UniProtKB | ChEBI)
Binding site57Ca2+ 1 (UniProtKB | ChEBI)
Binding site59Ca2+ 1 (UniProtKB | ChEBI)
Binding site62Ca2+ 1 (UniProtKB | ChEBI)
Binding site90Ca2+ 2 (UniProtKB | ChEBI)
Binding site92Ca2+ 2 (UniProtKB | ChEBI)
Binding site94Ca2+ 2 (UniProtKB | ChEBI)
Binding site96Ca2+ 2 (UniProtKB | ChEBI)
Binding site101Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functioncalcium ion binding

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Parvalbumin beta 2

Organism names

Accessions

  • Primary accession
    P86757

Subcellular Location

Phenotypes & Variants

Keywords

Protein family/group databases

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylalanine
ChainPRO_00003994161-108Parvalbumin beta 2

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-73EF-hand 1
Domain77-108EF-hand 2

Sequence similarities

Belongs to the parvalbumin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    108
  • Mass (Da)
    11,345
  • Last updated
    2010-10-05 v1
  • Checksum
    D6E3468745C4493C
AFSGILAEADIAAALKACEAAGTFNYKAFFAKVGLTGKSADDIKKAFFVIDQDKSGFIEEDELKLFLQVFSAGARALTDDETKAFLKAGDSDGDGAIGVEEWAALVKA

Features

Showing features for sequence uncertainty.

TypeIDPosition(s)Description
Sequence uncertainty5I or L
Sequence uncertainty6L or I
Sequence uncertainty11I or L
Sequence uncertainty15L or I
Sequence uncertainty16K or Q
Sequence uncertainty27K or Q
Sequence uncertainty32K or Q
Sequence uncertainty35L or I
Sequence uncertainty38K or Q
Sequence uncertainty43I or L
Sequence uncertainty44K or Q
Sequence uncertainty45K or Q
Sequence uncertainty50I or L
Sequence uncertainty52Q or K
Sequence uncertainty54K or Q
Sequence uncertainty58I or L
Sequence uncertainty63L or I
Sequence uncertainty64K or Q
Sequence uncertainty65L or I
Sequence uncertainty67L or I
Sequence uncertainty68Q or K
Sequence uncertainty77L or I
Sequence uncertainty83K or Q
Sequence uncertainty86L or I
Sequence uncertainty87K or Q
Sequence uncertainty97I or L
Sequence uncertainty105L or I
Sequence uncertainty107K or Q

Mass Spectrometry

Molecular mass is 11,379.812 Da. Determined by Electrospray.

Keywords

Similar Proteins

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