P85290 · NDKB_MERBI
- ProteinNucleoside diphosphate kinase B
- Genenme2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids128 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 39 | ATP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 70 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 81 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 91 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 94 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | lamellipodium | |
Cellular Component | nucleus | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | regulation of apoptotic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase B
- EC number
- Short namesNDK B; NDP kinase B
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Zeiogadaria > Gadariae > Gadiformes > Gadoidei > Merlucciidae > Merluccius
Accessions
- Primary accessionP85290
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000306186 | 1-128 | Nucleoside diphosphate kinase B | |||
Sequence: MEQTFIAIKPDGVQRGLCGEVMKFIQPMKHYLDLKDMPFYAGLCKYMSSGPVFAMVWEGEGIVKMMLGETNPADSKPGSIRGDFCINIGRNIIHGSDTVENAKMEVGLWFKPEEFVAYAEKAKAWVYE |
Keywords
- PTM
PTM databases
Structure
Sequence
- Sequence statusFragments
- Length128
- Mass (Da)14,407
- Last updated2007-10-02 v1
- Checksum0C2A199A17C40E69
Features
Showing features for non-adjacent residues.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-adjacent residues | 23-24 | |||||
Sequence: KF | ||||||
Non-adjacent residues | 27-28 | |||||
Sequence: PM | ||||||
Non-adjacent residues | 29-30 | |||||
Sequence: KH | ||||||
Non-adjacent residues | 64-65 | |||||
Sequence: KM |
Keywords
- Technical term