P85072 · AMPS1_LITPI

Function

function

Endonuclease, hydrolyzes highly polymerized RNA, poly(U) and poly(C), and the dinucleotides CpA and UpA. More active towards rCA than rUA or rUG. Has cytotoxic activity against cultured human submaxillary gland carcinoma cells.

Features

Showing features for active site, binding site.

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Type
IDPosition(s)Description
Active site15Proton acceptor
Binding site42-46substrate
Active site107Proton donor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionendonuclease activity
Molecular Functionnucleic acid binding
Molecular FunctionRNA nuclease activity
Biological Processdefense response to Gram-positive bacterium

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    P85072

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00002913071-114Amphinase-1
Disulfide bond26↔79
Glycosylation27N-linked (GlcNAc...) asparagine
Disulfide bond41↔85
Disulfide bond59↔100
Glycosylation67N-linked (GlcNAc...) asparagine
Glycosylation91N-linked (GlcNAc...) asparagine
Disulfide bond97↔114

Post-translational modification

There are at least five different forms arising from glycan heterogeneity.

Keywords

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    114
  • Mass (Da)
    13,071
  • Last updated
    2007-06-12 v1
  • MD5 Checksum
    B2621BE120FDE214E2CD2A8CD31FB0D2
KPKEDREWEKFKTKHITSQSVADFNCNRTMNDPAYTPDGQCKPVNTFIHSTTGPVKEICRRATGRVNKSSTQQFTLTTCKNPIRCKYSQSNTTNFICITCRDNYPVHFVKTGKC

Mass Spectrometry

Molecular mass is 14,932 Da. Determined by Electrospray. Major (most represented) glycoform 1.
Molecular mass is 14,729 Da. Determined by Electrospray. Major (second-most represented) glycoform 2.
Molecular mass is 15,298 Da. Determined by Electrospray. Minor glycoform 3.
Molecular mass is 14,568 Da. Determined by Electrospray. Minor glycoform 4.
Molecular mass is 15,095 Da. Determined by Electrospray. Minor (least represented) glycoform 5.

Keywords

Similar Proteins

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