P84097 · RHOG_CRICR

Function

function

Plays a role in immunological synaptic F-actin density and architecture organization (By similarity).
Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (By similarity).
Required for the formation of membrane ruffles during macropinocytosis (By similarity).
Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).
Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (By similarity).
Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (By similarity).
Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (By similarity).
Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (By similarity).

Features

Showing features for binding site.

119120406080100120140160180
TypeIDPosition(s)Description
Binding site10-17GTP (UniProtKB | ChEBI)
Binding site57-61GTP (UniProtKB | ChEBI)
Binding site115-118GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell projection
Cellular Componentcytoplasmic vesicle
Cellular Componentcytoskeleton
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionprotein kinase binding
Biological Processactivation of GTPase activity
Biological Processcell chemotaxis
Biological Processcortical cytoskeleton organization
Biological Processengulfment of apoptotic cell
Biological Processestablishment or maintenance of cell polarity
Biological Processmotor neuron axon guidance
Biological Processpositive regulation of protein localization to plasma membrane
Biological ProcessRac protein signal transduction
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of cell shape

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Rho-related GTP-binding protein RhoG

Gene names

    • Name
      RHOG
    • Synonyms
      ARHG

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Cricetus

Accessions

  • Primary accession
    P84097
  • Secondary accessions
    • P35238
    • Q8NI04

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, lipidation, propeptide.

Type
IDPosition(s)Description
ChainPRO_00000420261-188Rho-related GTP-binding protein RhoG
Modified residue138Phosphothreonine
Modified residue180Phosphothreonine
Modified residue188Cysteine methyl ester
Lipidation188S-geranylgeranyl cysteine
PropeptidePRO_0000042027189-191Removed in mature form

Keywords

Interaction

Subunit

Interacts with ARHGEF26 (By similarity).
Interacts with ARHGEF16 (By similarity).
Interacts with UNC13D; the interaction increases RhoG affinity to the membrane lipids, targets UNC13D to membrane lipids and facilitates cytotoxic granule (CG) docking to the plasma membrane (By similarity).

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif32-40Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    191
  • Mass (Da)
    21,309
  • Last updated
    2004-08-16 v1
  • Checksum
    0C4FE9C54140F499
MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X61588
EMBL· GenBank· DDBJ
CAA43785.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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