P84097 · RHOG_CRICR
- ProteinRho-related GTP-binding protein RhoG
- GeneRHOG
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids191 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Plays a role in immunological synaptic F-actin density and architecture organization (By similarity).
Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (By similarity).
Required for the formation of membrane ruffles during macropinocytosis (By similarity).
Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).
Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (By similarity).
Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (By similarity).
Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (By similarity).
Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (By similarity).
Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (By similarity).
Required for the formation of membrane ruffles during macropinocytosis (By similarity).
Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity).
Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (By similarity).
Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (By similarity).
Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (By similarity).
Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10-17 | GTP (UniProtKB | ChEBI) | |||
Binding site | 57-61 | GTP (UniProtKB | ChEBI) | |||
Binding site | 115-118 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell projection | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | cytoskeleton | |
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | protein kinase binding | |
Biological Process | activation of GTPase activity | |
Biological Process | cell chemotaxis | |
Biological Process | cortical cytoskeleton organization | |
Biological Process | engulfment of apoptotic cell | |
Biological Process | establishment or maintenance of cell polarity | |
Biological Process | motor neuron axon guidance | |
Biological Process | positive regulation of protein localization to plasma membrane | |
Biological Process | Rac protein signal transduction | |
Biological Process | regulation of actin cytoskeleton organization | |
Biological Process | regulation of cell shape |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRho-related GTP-binding protein RhoG
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Cricetus
Accessions
- Primary accessionP84097
- Secondary accessions
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue, lipidation, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000042026 | 1-188 | Rho-related GTP-binding protein RhoG | ||
Modified residue | 138 | Phosphothreonine | |||
Modified residue | 180 | Phosphothreonine | |||
Modified residue | 188 | Cysteine methyl ester | |||
Lipidation | 188 | S-geranylgeranyl cysteine | |||
Propeptide | PRO_0000042027 | 189-191 | Removed in mature form | ||
Keywords
- PTM
Interaction
Subunit
Interacts with ARHGEF26 (By similarity).
Interacts with ARHGEF16 (By similarity).
Interacts with UNC13D; the interaction increases RhoG affinity to the membrane lipids, targets UNC13D to membrane lipids and facilitates cytotoxic granule (CG) docking to the plasma membrane (By similarity).
Interacts with ARHGEF16 (By similarity).
Interacts with UNC13D; the interaction increases RhoG affinity to the membrane lipids, targets UNC13D to membrane lipids and facilitates cytotoxic granule (CG) docking to the plasma membrane (By similarity).
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length191
- Mass (Da)21,309
- Last updated2004-08-16 v1
- Checksum0C4FE9C54140F499
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X61588 EMBL· GenBank· DDBJ | CAA43785.1 EMBL· GenBank· DDBJ | mRNA |