P83721 · LEC1_CRAMO
- ProteinMannose/glucose-specific lectin Cramoll
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids234 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Glucose/D-mannose specific lectin.
Miscellaneous
Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 8 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 10 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 10 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 12 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 12 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 14 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 19 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 19 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 24 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 34 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 99-100 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: LY | ||||||
Binding site | 205 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 225 | a carbohydrate (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | D-glucose binding | |
Molecular Function | D-mannose binding | |
Molecular Function | metal ion binding |
Keywords
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMannose/glucose-specific lectin Cramoll
- Alternative names
- Cleaved into 2 chains
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > indigoferoid/millettioid clade > Phaseoleae > Cratylia
Accessions
- Primary accessionP83721
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000017591 | 1-116 | Cramoll alpha chain | |||
Sequence: ADTIVAVELDTYPNTDIGDPSYQHIGINIKSIRSKATTRWDVQNGKVGTAHISYNSVAKRLSAVVSYPGGSSATVSYDVDLNNILPEWVRVGLSASTGLYKETNTILSWSFTSKSN | ||||||
Chain | PRO_0000017592 | 117-234 | Cramoll beta chain | |||
Sequence: STADAQSLHFTFNQFSQSPKDLILQGDASTDSDGNLQLTRVSNGSPQSDSVGRALYYAPVHIWDKSAVVASFDATFTFLIKSPDREIADGIAFFIANTDSSIPHGSGGRLLGLFPDAN |
Post-translational modification
The alpha and beta chains are produced by partial proteolytic processing of the lectin precursor by an asparaginyl endopeptidase.
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusFragments
- Length234
- Mass (Da)25,130
- Last updated2004-02-02 v1
- Checksum6DC1F3FF1D3C1C58
Features
Showing features for non-adjacent residues.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-adjacent residues | 114-115 | |||||
Sequence: KS |
Keywords
- Technical term