P81917 · OR43A_DROME
- ProteinOdorant receptor 43a
- GeneOr43a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids376 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Involved in the behavioral responses to acetophenone, benzaldehyde, benzyl alcohol, cyclohexanone, and cyclohexanol.
Miscellaneous
The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | dendrite membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ionotropic olfactory receptor activity | |
Molecular Function | odorant binding | |
Molecular Function | olfactory receptor activity | |
Biological Process | detection of chemical stimulus involved in sensory perception of smell | |
Biological Process | sensory perception of smell | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameOdorant receptor 43a
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP81917
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-32 | Cytoplasmic | ||||
Sequence: MTIEDIGLVGINVRMWRHLAVLYPTPGSSWRK | ||||||
Transmembrane | 33-53 | Helical; Name=1 | ||||
Sequence: FAFVLPVTAMNLMQFVYLLRM | ||||||
Topological domain | 54-58 | Extracellular | ||||
Sequence: WGDLP | ||||||
Transmembrane | 59-79 | Helical; Name=2 | ||||
Sequence: AFILNMFFFSAIFNALMRTWL | ||||||
Topological domain | 80-123 | Cytoplasmic | ||||
Sequence: VIIKRRQFEEFLGQLATLFHSILDSTDEWGRGILRRAEREARNL | ||||||
Transmembrane | 124-144 | Helical; Name=3 | ||||
Sequence: AILNLSASFLDIVGALVSPLF | ||||||
Topological domain | 145-178 | Extracellular | ||||
Sequence: REERAHPFGLALPGVSMTSSPVYEVIYLAQLPTP | ||||||
Transmembrane | 179-199 | Helical; Name=4 | ||||
Sequence: LLLSMMYMPFVSLFAGLAIFG | ||||||
Topological domain | 200-247 | Cytoplasmic | ||||
Sequence: KAMLQILVHRLGQIGGEEQSEEERFQRLASCIAYHTQVMRYVWQLNKL | ||||||
Transmembrane | 248-268 | Helical; Name=5 | ||||
Sequence: VANIVAVEAIIFGSIICSLLF | ||||||
Topological domain | 269-276 | Extracellular | ||||
Sequence: CLNIITSP | ||||||
Transmembrane | 277-297 | Helical; Name=6 | ||||
Sequence: TQVISIVMYILTMLYVLFTYY | ||||||
Topological domain | 298-342 | Cytoplasmic | ||||
Sequence: NRANEICLENNRVAEAVYNVPWYEAGTRFRKTLLIFLMQTQHPME | ||||||
Transmembrane | 343-363 | Helical; Name=7 | ||||
Sequence: IRVGNVYPMTLAMFQSLLNAS | ||||||
Topological domain | 364-376 | Extracellular | ||||
Sequence: YSYFTMLRGVTGK |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000174244 | 1-376 | Odorant receptor 43a | |||
Sequence: MTIEDIGLVGINVRMWRHLAVLYPTPGSSWRKFAFVLPVTAMNLMQFVYLLRMWGDLPAFILNMFFFSAIFNALMRTWLVIIKRRQFEEFLGQLATLFHSILDSTDEWGRGILRRAEREARNLAILNLSASFLDIVGALVSPLFREERAHPFGLALPGVSMTSSPVYEVIYLAQLPTPLLLSMMYMPFVSLFAGLAIFGKAMLQILVHRLGQIGGEEQSEEERFQRLASCIAYHTQVMRYVWQLNKLVANIVAVEAIIFGSIICSLLFCLNIITSPTQVISIVMYILTMLYVLFTYYNRANEICLENNRVAEAVYNVPWYEAGTRFRKTLLIFLMQTQHPMEIRVGNVYPMTLAMFQSLLNASYSYFTMLRGVTGK |
Proteomic databases
Expression
Tissue specificity
Expressed with Orco in 20 sensory neurons on the distal edge of the antenna.
Gene expression databases
Interaction
Subunit
Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P81917 | Orco Q9VNB5 | 2 | EBI-15562282, EBI-15562228 |
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length376
- Mass (Da)43,090
- Last updated2000-12-01 v2
- Checksum1B3638FE7EA49606
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 154 | in Ref. 1; AAD26361 | ||||
Sequence: L → V | ||||||
Sequence conflict | 237-272 | in Ref. 4 | ||||
Sequence: Missing |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF127926 EMBL· GenBank· DDBJ | AAD26361.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF59280.1 EMBL· GenBank· DDBJ | Genomic DNA |