P81603 · DEFC_AEDAE

Function

function

Antibacterial peptide mostly active against Gram-positive bacteria.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Biological Processdefense response to Gram-positive bacterium
Biological Processinnate immune response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Defensin-C

Gene names

    • Name
      DEFC
    • ORF names
      AAEL003832

Organism names

  • Taxonomic identifier
  • Strains
    • Liverpool
    • LVPib12
    • REFM
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia

Accessions

  • Primary accession
    P81603
  • Secondary accessions
    • Q17EE4
    • Q9Y0F0
    • Q9Y0F1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant26in isoform C1
Natural variant34in isoform C1

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
PropeptidePRO_000000673624-59
ChainPRO_000000673760-99Defensin-C
Disulfide bond62↔89
Disulfide bond75↔95
Disulfide bond79↔97

Keywords

Proteomic databases

Expression

Tissue specificity

Hemolymph.

Induction

By bacterial infection.

Developmental stage

Expressed 30 minutes after infection and remained present through to 21 days. Expressed in white or callow pupae during metamorphosis, but no expression was seen in larvae.

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the invertebrate defensin family. Type 1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    99
  • Mass (Da)
    10,711
  • Last updated
    2007-08-21 v3
  • Checksum
    7914827671AF6709
MRTLTVVCFVALCLSAIFTTGNALPGELADDVRPYANSLFDELPEESYQAAVENFRLKRATCDLLSGFGVGDSACAAHCIARRNRGGYCNAKKVCVCRN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1S4F5Z5A0A1S4F5Z5_AEDAE557909499

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict5in Ref. 1; AAD40116/AAD40117
Sequence conflict22in Ref. 1; AAD40116/AAD40117
Sequence conflict83in Ref. 3; AA sequence and 4; AA sequence
Sequence conflict91in Ref. 3; AA sequence and 4; AA sequence

Polymorphism

There are two defensin C isoforms, C1 and C2 (shown here).

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF156092
EMBL· GenBank· DDBJ
AAD40116.2
EMBL· GenBank· DDBJ
mRNA
AF156093
EMBL· GenBank· DDBJ
AAD40117.2
EMBL· GenBank· DDBJ
mRNA
CH477283
EMBL· GenBank· DDBJ
EAT44832.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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