P81603 · DEFC_AEDAE
- ProteinDefensin-C
- GeneDEFC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Antibacterial peptide mostly active against Gram-positive bacteria.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Biological Process | defense response to Gram-positive bacterium | |
Biological Process | innate immune response |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDefensin-C
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia
Accessions
- Primary accessionP81603
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 26 | in isoform C1 | ||||
Sequence: G → E | ||||||
Natural variant | 34 | in isoform C1 | ||||
Sequence: P → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, propeptide, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MRTLTVVCFVALCLSAIFTTGNA | ||||||
Propeptide | PRO_0000006736 | 24-59 | ||||
Sequence: LPGELADDVRPYANSLFDELPEESYQAAVENFRLKR | ||||||
Chain | PRO_0000006737 | 60-99 | Defensin-C | |||
Sequence: ATCDLLSGFGVGDSACAAHCIARRNRGGYCNAKKVCVCRN | ||||||
Disulfide bond | 62↔89 | |||||
Sequence: CDLLSGFGVGDSACAAHCIARRNRGGYC | ||||||
Disulfide bond | 75↔95 | |||||
Sequence: CAAHCIARRNRGGYCNAKKVC | ||||||
Disulfide bond | 79↔97 | |||||
Sequence: CIARRNRGGYCNAKKVCVC |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Hemolymph.
Induction
By bacterial infection.
Developmental stage
Expressed 30 minutes after infection and remained present through to 21 days. Expressed in white or callow pupae during metamorphosis, but no expression was seen in larvae.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the invertebrate defensin family. Type 1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length99
- Mass (Da)10,711
- Last updated2007-08-21 v3
- Checksum7914827671AF6709
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1S4F5Z5 | A0A1S4F5Z5_AEDAE | 5579094 | 99 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 5 | in Ref. 1; AAD40116/AAD40117 | ||||
Sequence: T → I | ||||||
Sequence conflict | 22 | in Ref. 1; AAD40116/AAD40117 | ||||
Sequence: N → S | ||||||
Sequence conflict | 83 | in Ref. 3; AA sequence and 4; AA sequence | ||||
Sequence: R → G | ||||||
Sequence conflict | 91 | in Ref. 3; AA sequence and 4; AA sequence | ||||
Sequence: A → S |
Polymorphism
There are two defensin C isoforms, C1 and C2 (shown here).
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF156092 EMBL· GenBank· DDBJ | AAD40116.2 EMBL· GenBank· DDBJ | mRNA | ||
AF156093 EMBL· GenBank· DDBJ | AAD40117.2 EMBL· GenBank· DDBJ | mRNA | ||
CH477283 EMBL· GenBank· DDBJ | EAT44832.1 EMBL· GenBank· DDBJ | Genomic DNA |