P81068 · IRX1_MOUSE

  • Protein
    Iroquois-class homeodomain protein IRX-1
  • Gene
    Irx1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Features

Showing features for dna binding.

148050100150200250300350400450
TypeIDPosition(s)Description
DNA binding127-189Homeobox; TALE-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcell development
Biological Processmetanephros development
Biological Processneuron differentiation
Biological Processpositive regulation of gene expression
Biological Processproximal/distal pattern formation involved in metanephric nephron development
Biological Processregulation of transcription by RNA polymerase II
Biological Processresponse to organic cyclic compound
Biological Processspecification of loop of Henle identity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Iroquois-class homeodomain protein IRX-1
  • Alternative names
    • Homeodomain protein IRXA1
    • Iroquois homeobox protein 1

Gene names

    • Name
      Irx1
    • Synonyms
      Irxa1

Organism names

  • Taxonomic identifier
  • Strains
    • FVB/N
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P81068
  • Secondary accessions
    • G5E8H6
    • O55120
    • Q3UZB9
    • Q9JLL6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000491521-480Iroquois-class homeodomain protein IRX-1
Modified residue241Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is found in the loop of Henle in the S3 proximal tubule segment and in the thick ascending limb (TAL) of the distal tubule.

Developmental stage

First detected in the mesoderm at stage 7.5 dpc. During neurogenesis (9.5 dpc to 10.5 dpc), predominantly expressed along the anteroposterior axis of the CNS in the mesencephalon, metencephalon, rhombencephalon and spinal cord, with expression excluded from the midbrain-hindbrain junction. Beginning at 9.5 dpc, expression is found in the epithelial component of the branchial arches and foregut. At later stages, expressed in somites. At 10.5 dpc, expressed in the cephalic mesenchyme surrounding the optic vesicle. By 12.5 dpc, expression remains in the mesenchyme and also begins in the neuroretina, and at 16.5 dpc expression is exclusively located in the inner neuroblast layers of the neuroretina. Starting at the otic vesicle stage, shows regionalized expression in the developing inner ear with expression in the entire otic vesicle from 10.5 dpc onwards. Expressed in distinct patterns in the developing limb buds from 10.5 dpc onwards. Expressed in the developing heart in the ventricular septum from the onset of its formation (10.5 dpc) onward. In fetal stages, expression becomes confined to the myocardium of the atrioventricular bundle and bundle branches of the forming ventricular conduction system.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias190-212Basic and acidic residues
Region190-285Disordered
Compositional bias213-245Acidic residues
Compositional bias263-277Polar residues
Region318-354Disordered
Region401-480Disordered
Compositional bias403-417Pro residues
Compositional bias447-464Polar residues

Sequence similarities

Belongs to the TALE/IRO homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    50,169
  • Last updated
    2012-10-03 v4
  • Checksum
    38D141E4C127A6C1
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGTAELGAGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNEDEEDKAEAPRARVAPPASARDQSSPLSAAETLKSQDSPLGLVKEVSEPGSTRLLSPGAAAVGLQGAPHSKPKIWSLAETATSPDGAPKASPPPPSSHASAHGPPSGSPLQHPAFLPSHGLYTCHIGKFSNWTNGAFLAQGSLLNMRSFLGVSAPHAAPHGPHLTAPPPPQPPVQVATGVLHGEKASARSSPALPERDLVTRPDSPPQQLKSPFQPVRDNSLAPQEGTPRILAALPSA

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1Y7VJ15A0A1Y7VJ15_MOUSEIrx186
A0A1Y7VIS3A0A1Y7VIS3_MOUSEIrx1273

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict73in Ref. 3; BAE21938
Compositional bias190-212Basic and acidic residues
Sequence conflict197in Ref. 1; AAF63954
Compositional bias213-245Acidic residues
Sequence conflict257in Ref. 1; AAF63954
Compositional bias263-277Polar residues
Compositional bias403-417Pro residues
Compositional bias447-464Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF165984
EMBL· GenBank· DDBJ
AAF63954.1
EMBL· GenBank· DDBJ
mRNA
AK133937
EMBL· GenBank· DDBJ
BAE21938.1
EMBL· GenBank· DDBJ
mRNA
CT009684
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466563
EMBL· GenBank· DDBJ
EDL37041.1
EMBL· GenBank· DDBJ
Genomic DNA
Y15002
EMBL· GenBank· DDBJ
CAA75234.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp