P80145 · FRIH_ANAPL

Function

function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity).
Inhibits translation of various mRNA species in vitro. Associates with a 35S prosome-like particle that contains non-translated mRNAs in a complex with proteins. May be involved in pre-translational regulation of some mRNA.

Catalytic activity

Features

Showing features for binding site.

118120406080100120140160180
TypeIDPosition(s)Description
Binding site27Fe cation 1 (UniProtKB | ChEBI)
Binding site62Fe cation 1 (UniProtKB | ChEBI)
Binding site62Fe cation 2 (UniProtKB | ChEBI)
Binding site65Fe cation 1 (UniProtKB | ChEBI)
Binding site107Fe cation 2 (UniProtKB | ChEBI)
Binding site141Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentautophagosome
Cellular Componentcytoplasmic vesicle
Cellular Componentlysosome
Molecular Functionferric iron binding
Molecular Functionferrous iron binding
Molecular Functionferroxidase activity
Molecular FunctionRNA binding
Biological Processintracellular sequestering of iron ion
Biological Processiron ion transport
Biological Processnegative regulation of ferroptosis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ferritin heavy chain
  • EC number
  • Short names
    Ferritin H subunit
  • Alternative names
    • Prosome-like particle
      (PLP
      )
    • RNP particle

Gene names

    • Name
      FTH1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Anseriformes > Anatidae > Anatinae > Anas

Accessions

  • Primary accession
    P80145
  • Secondary accessions
    • L7XWS8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002010561-181Ferritin heavy chain

Expression

Tissue specificity

Expressed in erythroblasts (at protein level) (PubMed:1499559).
Expressed in heart, liver, spleen, lung, kidney, large intestine, small intestine, muscle, glandular stomach, ovary and oviduct (PubMed:24981929).

Induction

By duck hepatitis virus type I (DHV-1) (PubMed:24981929).
By polyinosinic:polycytidylic acid (poly I:C) which mimicks viral double-stranded RNA (PubMed:1499559).

Interaction

Subunit

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-159Ferritin-like diiron

Sequence similarities

Belongs to the ferritin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    181
  • Mass (Da)
    21,232
  • Last updated
    2023-06-28 v2
  • Checksum
    FB0CC1420D209BA0
MATPLSQVRQNYHQDCEAAVNRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWENGLTAMECALHLEKNVNQSLLELHKLATEKNDPHLCDFIETHYLDEQVKAIKELGDHVTNLRKMGAPKYGMAEYLFDKHTLGHSDES

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict180-181in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC117386
EMBL· GenBank· DDBJ
AGD91914.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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