P80145 · FRIH_ANAPL
- ProteinFerritin heavy chain
- GeneFTH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids181 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity).
Inhibits translation of various mRNA species in vitro. Associates with a 35S prosome-like particle that contains non-translated mRNAs in a complex with proteins. May be involved in pre-translational regulation of some mRNA.
Catalytic activity
- 4 Fe2+ + O2 + 4 H+ = 4 Fe3+ + 2 H2O
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 27 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 62 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 62 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 65 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 107 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 141 | Fe cation 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | lysosome | |
Molecular Function | ferric iron binding | |
Molecular Function | ferrous iron binding | |
Molecular Function | ferroxidase activity | |
Molecular Function | RNA binding | |
Biological Process | intracellular sequestering of iron ion | |
Biological Process | iron ion transport | |
Biological Process | negative regulation of ferroptosis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFerritin heavy chain
- EC number
- Short namesFerritin H subunit
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Anseriformes > Anatidae > Anatinae > Anas
Accessions
- Primary accessionP80145
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000201056 | 1-181 | Ferritin heavy chain | ||
Interaction
Subunit
Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Structure
Sequence
- Sequence statusComplete
- Length181
- Mass (Da)21,232
- Last updated2023-06-28 v2
- ChecksumFB0CC1420D209BA0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 180-181 | in Ref. 2; AA sequence | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KC117386 EMBL· GenBank· DDBJ | AGD91914.1 EMBL· GenBank· DDBJ | mRNA |