P80109 · PHLD_BOVIN

  • Protein
    Phosphatidylinositol-glycan-specific phospholipase D
  • Gene
    GPLD1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Cellular Componenthigh-density lipoprotein particle
Cellular Componentintracellular membrane-bounded organelle
Molecular Functionglycosylphosphatidylinositol phospholipase D activity
Molecular Functionsodium channel regulator activity
Biological Processcell migration involved in sprouting angiogenesis
Biological Processcellular response to calcium ion
Biological Processcellular response to cholesterol
Biological Processcellular response to insulin stimulus
Biological Processcellular response to pH
Biological Processcellular response to triglyceride
Biological Processcellular response to xenobiotic stimulus
Biological Processchondrocyte differentiation
Biological Processcomplement receptor mediated signaling pathway
Biological ProcessGPI anchor release
Biological Processinsulin receptor signaling pathway
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of triglyceride catabolic process
Biological Processossification
Biological Processphosphatidylcholine metabolic process
Biological Processpositive regulation of alkaline phosphatase activity
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of endothelial cell migration
Biological Processpositive regulation of glucose metabolic process
Biological Processpositive regulation of high-density lipoprotein particle clearance
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processpositive regulation of membrane protein ectodomain proteolysis
Biological Processpositive regulation of secretion
Biological Processpositive regulation of triglyceride biosynthetic process
Biological Processregulation of cellular response to insulin stimulus
Biological Processresponse to glucose
Biological Processtransepithelial transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol-glycan-specific phospholipase D
  • EC number
  • Short names
    PI-G PLD
  • Alternative names
    • Glycoprotein phospholipase D
    • Glycosyl-phosphatidylinositol-specific phospholipase D (GPI-PLD; GPI-specific phospholipase D)

Gene names

    • Name
      GPLD1
    • Synonyms
      PIGPLD

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    P80109

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis834Severe loss of enzymatic activity.

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_000002205324-839Phosphatidylinositol-glycan-specific phospholipase D
Glycosylation94N-linked (GlcNAc...) asparagine
Glycosylation271N-linked (GlcNAc...) asparagine
Glycosylation292N-linked (GlcNAc...) asparagine
Glycosylation307N-linked (GlcNAc...) asparagine
Glycosylation321N-linked (GlcNAc...) asparagine
Glycosylation500N-linked (GlcNAc...) asparagine
Glycosylation590N-linked (GlcNAc...) asparagine
Glycosylation658N-linked (GlcNAc...) asparagine

Post-translational modification

Glycosylated.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat365-427FG-GAP 1
Repeat434-496FG-GAP 2
Repeat498-558FG-GAP 3
Repeat562-622FG-GAP 4
Repeat632-692FG-GAP 5
Repeat703-769FG-GAP 6
Repeat787-839FG-GAP 7

Sequence similarities

Belongs to the GPLD1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    839
  • Mass (Da)
    92,602
  • Last updated
    1993-07-01 v1
  • Checksum
    F9BFF8A00226BF40
MSAFRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYRELYGRIVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPAASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPRIDLDLDKEAHGILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSREKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGLDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict181in Ref. 2; AA sequence
Sequence conflict184in Ref. 2; AA sequence
Sequence conflict235in Ref. 2; AA sequence
Sequence conflict634in Ref. 2; AA sequence
Sequence conflict777in Ref. 2; AA sequence
Sequence conflict780in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M60804
EMBL· GenBank· DDBJ
AAA30721.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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