P80078 · GMSS_CLOCO

  • Protein
    Glutamate mutase sigma subunit
  • Gene
    glmS
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).

Catalytic activity

Cofactor

adenosylcob(III)alamin (UniProtKB | Rhea| CHEBI:18408 )

Activity regulation

Competitively inhibited by (2S,4S)-4-fluoroglutamate, 2-methyleneglutarate, (2R,3RS)-3-fluoroglutamate and (S)-3-methylitaconate.

Pathway

Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13-17adenosylcob(III)alamin (UniProtKB | ChEBI)
Binding site16Co (UniProtKB | ChEBI) of adenosylcob(III)alamin (UniProtKB | ChEBI); axial binding residue
Binding site61-63adenosylcob(III)alamin (UniProtKB | ChEBI)
Binding site93-97adenosylcob(III)alamin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethylaspartate mutase activity
Biological Processanaerobic glutamate catabolic process
Biological Processglutamate catabolic process via L-citramalate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate mutase sigma subunit
  • EC number
  • Alternative names
    • Glutamate mutase S chain
    • Glutamate mutase small subunit
    • Methylaspartate mutase

Gene names

    • Name
      glmS

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 17787 / DSM 1285 / NCIB 10633
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium

Accessions

  • Primary accession
    P80078
  • Secondary accessions
    • Q60144

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002164431-137Glutamate mutase sigma subunit

Interaction

Subunit

Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P80078glmE P800772EBI-1028147, EBI-1028142

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-137B12-binding

Sequence similarities

Belongs to the methylaspartate mutase GlmS subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    137
  • Mass (Da)
    14,812
  • Last updated
    2001-12-13 v2
  • Checksum
    D9C5BF8DE5D1E878
MEKKTIVLGVIGSDCHAVGNKILDHAFTNAGFNVVNIGVLSPQEVFIKAAIETKADAILLSSLYGQGEIDCKGLRQKCDEAGLEGILLYVGGNIVVGKQHWPDVEKRFKDMGYDRVYAPGTPPEVGIADLKKDLNIE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X80997
EMBL· GenBank· DDBJ
CAA56921.1
EMBL· GenBank· DDBJ
Genomic DNA
X75890
EMBL· GenBank· DDBJ
CAA53484.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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