P80002 · PRT2_SEPOF

Function

function

Cuttlefish spermiogenesis is characterized by a double nuclear protein transition: histones -> spermatid-specific proteins (T1/T2) -> protamines (SP1/SP2). The protamines compact sperm DNA into a highly condensed, stable and inactive complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Biological Processcell differentiation
Biological Processchromosome condensation
Biological Processspermatogenesis

Keywords

Names & Taxonomy

Protein names

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Cephalopoda > Coleoidea > Decapodiformes > Sepiida > Sepiina > Sepiidae > Sepia

Accessions

  • Primary accession
    P80002

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000258251-77Spermatid-specific protein T2
ChainPRO_00000458752-77Spermatid-specific protein T2B
ChainPRO_000002582622-77Sperm protamine SP2

Post-translational modification

Phosphorylation occurs at different degrees. The triphosphorylated form may be predominant in T2. SP2 appears to be phosphorylated in elongated spermatids, but dephosphorylated in mature sperm cells.

Keywords

Expression

Tissue specificity

Testis.

Developmental stage

Spermiogenesis.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-21Hydrophobic
Region1-77Disordered
Compositional bias20-77Basic residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    77
  • Mass (Da)
    10,485
  • Last updated
    1991-11-01 v2
  • MD5 Checksum
    B92E38C973D0AC7760169705CB1448A6
MKVAANTSKMLVEKLDLLKGGRRRRRRSRRRRRSRRRRSRSPYRRRYRRRRRRRRSRRRRRYRRRRSYSRRRYRRRR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias20-77Basic residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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