P79748 · 5HT1D_TAKRU
- Protein5-hydroxytryptamine receptor 1D
- Genehtr1d
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled serotonin receptor activity | |
Molecular Function | neurotransmitter receptor activity | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | adenylate cyclase-inhibiting serotonin receptor signaling pathway | |
Biological Process | chemical synaptic transmission | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
Biological Process | regulation of behavior | |
Biological Process | regulation of locomotion | |
Biological Process | smooth muscle contraction | |
Biological Process | vasoconstriction |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended name5-hydroxytryptamine receptor 1D
- Short names5-HT-1D; 5-HT1D; 5HT1D
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Tetraodontiformes > Tetradontoidea > Tetraodontidae > Takifugu
Accessions
- Primary accessionP79748
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 37-62 | Helical; Name=1 | ||||
Sequence: ISVSVVLAIVTLATMLSNAFVIATIF | ||||||
Transmembrane | 74-95 | Helical; Name=2 | ||||
Sequence: LIGSLAVTDMLVSILVMPISIV | ||||||
Transmembrane | 108-132 | Helical; Name=3 | ||||
Sequence: VCDIWLSSDITFCTASILHLCVIAL | ||||||
Transmembrane | 153-174 | Helical; Name=4 | ||||
Sequence: AAVMVAVVWVISISISMPPLFW | ||||||
Transmembrane | 193-216 | Helical; Name=5 | ||||
Sequence: ISYTLYSTFGAFYVPTVLLIILYG | ||||||
Transmembrane | 306-331 | Helical; Name=6 | ||||
Sequence: KTLGIILGAFIICWLPFFVVTLVWAI | ||||||
Transmembrane | 340-363 | Helical; Name=7 | ||||
Sequence: LLFDVFTWLGYLNSLINPVIYTVF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068932 | 1-379 | 5-hydroxytryptamine receptor 1D | |||
Sequence: MELDNNSLDYFSSNFTDIPSNTTVAHWTEATLLGLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLAVTDMLVSILVMPISIVYTVSKTWSLGQIVCDIWLSSDITFCTASILHLCVIALDRYWAITDALEYSKRRTMRRAAVMVAVVWVISISISMPPLFWRQAKAHEELKECMVNTDQISYTLYSTFGAFYVPTVLLIILYGRIYVAARSRIFKTPSYSGKRFTTAQLIQTSAGSSLCSLNSASNQEAHLHSGAGGEGGGSPLFVNSVKVKLADNVLERKRLCAARERKATKTLGIILGAFIICWLPFFVVTLVWAICKECSFDPLLFDVFTWLGYLNSLINPVIYTVFNDEFKQAFQKLIKFRR | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 14 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 21 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 109↔186 | |||||
Sequence: CDIWLSSDITFCTASILHLCVIALDRYWAITDALEYSKRRTMRRAAVMVAVVWVISISISMPPLFWRQAKAHEELKEC |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 133-135 | DRY motif; important for ligand-induced conformation changes | ||||
Sequence: DRY | ||||||
Motif | 356-360 | NPxxY motif; important for ligand-induced conformation changes and signaling | ||||
Sequence: NPVIY |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length379
- Mass (Da)42,302
- Last updated1997-05-01 v1
- Checksum99B6E2C0379EBC78
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X83865 EMBL· GenBank· DDBJ | CAA58745.1 EMBL· GenBank· DDBJ | Genomic DNA |