P79748 · 5HT1D_TAKRU

Function

function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters.

Features

Showing features for binding site.

137950100150200250300350
TypeIDPosition(s)Description
Binding site116serotonin (UniProtKB | ChEBI)
Binding site120serotonin (UniProtKB | ChEBI)
Binding site326serotonin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular FunctionG protein-coupled serotonin receptor activity
Molecular Functionneurotransmitter receptor activity
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-inhibiting serotonin receptor signaling pathway
Biological Processchemical synaptic transmission
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processregulation of behavior
Biological Processregulation of locomotion
Biological Processsmooth muscle contraction
Biological Processvasoconstriction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    5-hydroxytryptamine receptor 1D
  • Short names
    5-HT-1D; 5-HT1D; 5HT1D
  • Alternative names
    • F1D
    • Serotonin receptor 1D

Gene names

    • Name
      htr1d

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Tetraodontiformes > Tetradontoidea > Tetraodontidae > Takifugu

Accessions

  • Primary accession
    P79748

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane37-62Helical; Name=1
Transmembrane74-95Helical; Name=2
Transmembrane108-132Helical; Name=3
Transmembrane153-174Helical; Name=4
Transmembrane193-216Helical; Name=5
Transmembrane306-331Helical; Name=6
Transmembrane340-363Helical; Name=7

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000689321-3795-hydroxytryptamine receptor 1D
Glycosylation5N-linked (GlcNAc...) asparagine
Glycosylation14N-linked (GlcNAc...) asparagine
Glycosylation21N-linked (GlcNAc...) asparagine
Disulfide bond109↔186

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif133-135DRY motif; important for ligand-induced conformation changes
Motif356-360NPxxY motif; important for ligand-induced conformation changes and signaling

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    42,302
  • Last updated
    1997-05-01 v1
  • Checksum
    99B6E2C0379EBC78
MELDNNSLDYFSSNFTDIPSNTTVAHWTEATLLGLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLAVTDMLVSILVMPISIVYTVSKTWSLGQIVCDIWLSSDITFCTASILHLCVIALDRYWAITDALEYSKRRTMRRAAVMVAVVWVISISISMPPLFWRQAKAHEELKECMVNTDQISYTLYSTFGAFYVPTVLLIILYGRIYVAARSRIFKTPSYSGKRFTTAQLIQTSAGSSLCSLNSASNQEAHLHSGAGGEGGGSPLFVNSVKVKLADNVLERKRLCAARERKATKTLGIILGAFIICWLPFFVVTLVWAICKECSFDPLLFDVFTWLGYLNSLINPVIYTVFNDEFKQAFQKLIKFRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X83865
EMBL· GenBank· DDBJ
CAA58745.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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