P79741 · PESC_DANRE

Function

function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular ComponentPeBoW complex
Cellular Componentpreribosome, large subunit precursor
Molecular Functionribonucleoprotein complex binding
Molecular FunctionRNA binding
Biological Processexocrine pancreas development
Biological Processmaturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processoligodendrocyte differentiation
Biological Processregulation of cell cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pescadillo

Gene names

    • Name
      pes
    • ORF names
      si:dkeyp-86g2.3

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    P79741
  • Secondary accessions
    • A2BGH4
    • B1H1I9
    • Q7ZU09
    • Q9I906

Proteomes

    • Identifier
    • Component
      Alternate scaffold 5, Chromosome 5

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Embryos exhibit smaller eyes, a reduced brain and visceral skeleton, shortened fins and a lack of expansion of liver and gut, and die on day 6 of development.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001861901-583Pescadillo

Proteomic databases

Expression

Developmental stage

Widely and highly expressed during the first 3 days of embryogenesis. Prominent sites of expression are the eyes and optic tectum on day 1, the fin buds, liver primordium, and gut on day 2, and the branchial arches on day 3.

Gene expression databases

Interaction

Subunit

Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil275-329
Domain323-416BRCT
Region448-526Disordered
Compositional bias454-489Acidic residues
Compositional bias512-526Basic and acidic residues
Compositional bias558-576Basic and acidic residues
Region558-583Disordered

Sequence similarities

Belongs to the pescadillo family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    583
  • Mass (Da)
    67,898
  • Last updated
    2009-05-05 v2
  • Checksum
    454C6D59F83DFEBF
MGGLQKKKYESGSATNYITRNKARKKLSLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTYYLLKDIRFLLHEPIVGKFREYKIFVRKLRKAYGKAEWSAVERLKENKPGYKLDHIIKERYPTFIDALRDVDDALSMCFLFSTFARTGKCHVQTIQLCRRLSVEWMNYIISSRSLRKVFLSIKGIYYQAEVLGQTITWIVPYQFAHNHPTDVDYRVMATFTELYTTLLGFVNFRLYQTLNLVYPPKLDGQGEISLKAEFEEDYALESESYTEKLSALSASLARMVASVEEEEAELDHFPTEGEDQEKMEVREKMEQQQSKQKKLFEGLKFFLNREVPRESLAFVIRCFGGEVSWDKSLCIGSTYEATDETITHHIVDRPSMDKQYINRYYIQPQWVYDSVNAKIQLPVEEYFLGVTLPPHLSPFVEETEGDYVPPEKLKLMALQRGEKPQAEEDEEEEGEEEEDDEEDEEDDEQSEDEEEAEEEANLAEMEEKRSQGKSLSVKVTPGKAKAENRARAAEEEKAEEKRLAIMMMKKKEKYLYDKIMFGKKRKVREANKLAAKRKAHDDASKADKKKKKKKC

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict49in Ref. 3; AAH49339
Sequence conflict172in Ref. 3; AAI60624
Sequence conflict199in Ref. 3; AAI60624
Compositional bias454-489Acidic residues
Compositional bias512-526Basic and acidic residues
Compositional bias558-576Basic and acidic residues
Sequence conflict574in Ref. 3; AAH49339
Sequence conflict576in Ref. 1; AAB61138 and 3; AAH49339/AAI60624

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U77627
EMBL· GenBank· DDBJ
AAB61138.1
EMBL· GenBank· DDBJ
mRNA
BX470167
EMBL· GenBank· DDBJ
CAM16783.2
EMBL· GenBank· DDBJ
Genomic DNA
CU459127
EMBL· GenBank· DDBJ
CAM16783.2
EMBL· GenBank· DDBJ
Genomic DNA
CU459127
EMBL· GenBank· DDBJ
CAQ14501.1
EMBL· GenBank· DDBJ
Genomic DNA
BX470167
EMBL· GenBank· DDBJ
CAQ14501.1
EMBL· GenBank· DDBJ
Genomic DNA
AB046115
EMBL· GenBank· DDBJ
BAB01764.1
EMBL· GenBank· DDBJ
Genomic DNA
BC049339
EMBL· GenBank· DDBJ
AAH49339.1
EMBL· GenBank· DDBJ
mRNA
BC160624
EMBL· GenBank· DDBJ
AAI60624.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp