P79741 · PESC_DANRE
- ProteinPescadillo
- Genepes
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids583 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | PeBoW complex | |
Cellular Component | preribosome, large subunit precursor | |
Molecular Function | ribonucleoprotein complex binding | |
Molecular Function | RNA binding | |
Biological Process | exocrine pancreas development | |
Biological Process | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | oligodendrocyte differentiation | |
Biological Process | regulation of cell cycle |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePescadillo
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionP79741
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Embryos exhibit smaller eyes, a reduced brain and visceral skeleton, shortened fins and a lack of expansion of liver and gut, and die on day 6 of development.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000186190 | 1-583 | Pescadillo | |||
Sequence: MGGLQKKKYESGSATNYITRNKARKKLSLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTYYLLKDIRFLLHEPIVGKFREYKIFVRKLRKAYGKAEWSAVERLKENKPGYKLDHIIKERYPTFIDALRDVDDALSMCFLFSTFARTGKCHVQTIQLCRRLSVEWMNYIISSRSLRKVFLSIKGIYYQAEVLGQTITWIVPYQFAHNHPTDVDYRVMATFTELYTTLLGFVNFRLYQTLNLVYPPKLDGQGEISLKAEFEEDYALESESYTEKLSALSASLARMVASVEEEEAELDHFPTEGEDQEKMEVREKMEQQQSKQKKLFEGLKFFLNREVPRESLAFVIRCFGGEVSWDKSLCIGSTYEATDETITHHIVDRPSMDKQYINRYYIQPQWVYDSVNAKIQLPVEEYFLGVTLPPHLSPFVEETEGDYVPPEKLKLMALQRGEKPQAEEDEEEEGEEEEDDEEDEEDDEQSEDEEEAEEEANLAEMEEKRSQGKSLSVKVTPGKAKAENRARAAEEEKAEEKRLAIMMMKKKEKYLYDKIMFGKKRKVREANKLAAKRKAHDDASKADKKKKKKKC |
Proteomic databases
Expression
Developmental stage
Widely and highly expressed during the first 3 days of embryogenesis. Prominent sites of expression are the eyes and optic tectum on day 1, the fin buds, liver primordium, and gut on day 2, and the branchial arches on day 3.
Gene expression databases
Interaction
Subunit
Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 275-329 | |||||
Sequence: EKLSALSASLARMVASVEEEEAELDHFPTEGEDQEKMEVREKMEQQQSKQKKLFE | ||||||
Domain | 323-416 | BRCT | ||||
Sequence: KQKKLFEGLKFFLNREVPRESLAFVIRCFGGEVSWDKSLCIGSTYEATDETITHHIVDRPSMDKQYINRYYIQPQWVYDSVNAKIQLPVEEYFL | ||||||
Region | 448-526 | Disordered | ||||
Sequence: RGEKPQAEEDEEEEGEEEEDDEEDEEDDEQSEDEEEAEEEANLAEMEEKRSQGKSLSVKVTPGKAKAENRARAAEEEKA | ||||||
Compositional bias | 454-489 | Acidic residues | ||||
Sequence: AEEDEEEEGEEEEDDEEDEEDDEQSEDEEEAEEEAN | ||||||
Compositional bias | 512-526 | Basic and acidic residues | ||||
Sequence: AKAENRARAAEEEKA | ||||||
Compositional bias | 558-576 | Basic and acidic residues | ||||
Sequence: ANKLAAKRKAHDDASKADK | ||||||
Region | 558-583 | Disordered | ||||
Sequence: ANKLAAKRKAHDDASKADKKKKKKKC |
Sequence similarities
Belongs to the pescadillo family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length583
- Mass (Da)67,898
- Last updated2009-05-05 v2
- Checksum454C6D59F83DFEBF
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 49 | in Ref. 3; AAH49339 | ||||
Sequence: K → R | ||||||
Sequence conflict | 172 | in Ref. 3; AAI60624 | ||||
Sequence: I → L | ||||||
Sequence conflict | 199 | in Ref. 3; AAI60624 | ||||
Sequence: I → V | ||||||
Compositional bias | 454-489 | Acidic residues | ||||
Sequence: AEEDEEEEGEEEEDDEEDEEDDEQSEDEEEAEEEAN | ||||||
Compositional bias | 512-526 | Basic and acidic residues | ||||
Sequence: AKAENRARAAEEEKA | ||||||
Compositional bias | 558-576 | Basic and acidic residues | ||||
Sequence: ANKLAAKRKAHDDASKADK | ||||||
Sequence conflict | 574 | in Ref. 3; AAH49339 | ||||
Sequence: A → E | ||||||
Sequence conflict | 576 | in Ref. 1; AAB61138 and 3; AAH49339/AAI60624 | ||||
Sequence: Missing |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U77627 EMBL· GenBank· DDBJ | AAB61138.1 EMBL· GenBank· DDBJ | mRNA | ||
BX470167 EMBL· GenBank· DDBJ | CAM16783.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CU459127 EMBL· GenBank· DDBJ | CAM16783.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CU459127 EMBL· GenBank· DDBJ | CAQ14501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX470167 EMBL· GenBank· DDBJ | CAQ14501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB046115 EMBL· GenBank· DDBJ | BAB01764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC049339 EMBL· GenBank· DDBJ | AAH49339.1 EMBL· GenBank· DDBJ | mRNA | ||
BC160624 EMBL· GenBank· DDBJ | AAI60624.1 EMBL· GenBank· DDBJ | mRNA |