P79716 · CP1A1_DICLA

Function

function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

152050100150200250300350400450500
TypeIDPosition(s)Description
Binding site230substrate
Binding site464Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionaromatase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionsteroid 17-alpha-monooxygenase activity
Biological Processhormone biosynthetic process
Biological Processprogesterone metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome P450 1A1
  • EC number
  • Alternative names
    • CYPIA1

Gene names

    • Name
      cyp1a1

Organism names

Accessions

  • Primary accession
    P79716

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000516351-520Cytochrome P450 1A1

Structure

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    520
  • Mass (Da)
    58,744
  • Last updated
    1997-05-01 v1
  • Checksum
    86761584B28E57FB
MVLMILPFIGSVSVSESLVALTTVCLVYLILKFFRTEIPEGLHRLPGPKPLPLIGNVLEVGNKPYLSLTAMSKRYGDVFRFRLGMRPSGCLSGSETVRKALIKQGDEFAGRPDLYSFRFINDGKSLAFSTDKAGVWRALRKLAYSALRSFSSLEESTPRDSCVLEEHSAKEGEYLYSNMLNAVMKVTGSFDPFRHIVVSVANVICGMCFGRRYGHNDQELLSLVNLSDPFGQVVGSGNPADFIPVLQFLPSTTMKNFMDINARFNKFVQKIVSEHYTTYDKDNIRDITDSLIDHCEDRKLDENANVQMSDEKIVGIVNDLFGAGFDTISTALSWSVMYLVAYPEIEERLYQELKENVGLDRTPLLCDRPNLPFLEAFILEIFRHSSFLPFTIPHCTSKDTSLNGYFIPKDTCVFINQWQINHDPELWKDPSSFNPDRFLSADGTELNKLEGEKVMVFGLGKRRCIGEVIARNGVFLFLAIIVQKLHFKTLPGEPLDMTPEYGLTMKHKRCHLRATMRASE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U78316
EMBL· GenBank· DDBJ
AAB36951.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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