P79716 · CP1A1_DICLA
- ProteinCytochrome P450 1A1
- Genecyp1a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids520 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity
- an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H+
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | steroid 17-alpha-monooxygenase activity | |
Biological Process | hormone biosynthetic process | |
Biological Process | progesterone metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome P450 1A1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Moronidae > Dicentrarchus
Accessions
- Primary accessionP79716
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Peripheral membrane protein
Microsome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000051635 | 1-520 | Cytochrome P450 1A1 | |||
Sequence: MVLMILPFIGSVSVSESLVALTTVCLVYLILKFFRTEIPEGLHRLPGPKPLPLIGNVLEVGNKPYLSLTAMSKRYGDVFRFRLGMRPSGCLSGSETVRKALIKQGDEFAGRPDLYSFRFINDGKSLAFSTDKAGVWRALRKLAYSALRSFSSLEESTPRDSCVLEEHSAKEGEYLYSNMLNAVMKVTGSFDPFRHIVVSVANVICGMCFGRRYGHNDQELLSLVNLSDPFGQVVGSGNPADFIPVLQFLPSTTMKNFMDINARFNKFVQKIVSEHYTTYDKDNIRDITDSLIDHCEDRKLDENANVQMSDEKIVGIVNDLFGAGFDTISTALSWSVMYLVAYPEIEERLYQELKENVGLDRTPLLCDRPNLPFLEAFILEIFRHSSFLPFTIPHCTSKDTSLNGYFIPKDTCVFINQWQINHDPELWKDPSSFNPDRFLSADGTELNKLEGEKVMVFGLGKRRCIGEVIARNGVFLFLAIIVQKLHFKTLPGEPLDMTPEYGLTMKHKRCHLRATMRASE |
Structure
Sequence
- Sequence statusComplete
- Length520
- Mass (Da)58,744
- Last updated1997-05-01 v1
- Checksum86761584B28E57FB
Keywords
- Technical term