P79430 · CP192_PIG

  • Protein
    Aromatase 2
  • Gene
    CYP19A2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site437Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionaromatase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Biological Processfemale gonad development
Biological Processresponse to estradiol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aromatase 2
  • EC number
  • Alternative names
    • CYPXIXA2
    • Cytochrome P-450AROM
    • Cytochrome P450 19 type II
    • Estrogen synthase

Gene names

    • Name
      CYP19A2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    P79430
  • Secondary accessions
    • O02847

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000519591-503Aromatase 2

Proteomic databases

Structure

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    58,063
  • Last updated
    1997-05-01 v1
  • Checksum
    FAC8821A68AC5F77
MVLEMLNPMYYKITSMVSEVVPFASIAVLLLTGFLLLLWNYENTSSIPSPGYFLGIGPLISHFRFLWMGIGSACNYYNEMYGEFMRVWIGGEETLIISKSSSVFHVMKHSHYTSRFGSKPGLECIGMYEKGIIFNNDPALWKAVRTYFMKALSGPGLVRMVTVCADSITKHLDKLEEVRNDLGYVDVLTLMRRIMLDTSNNLFLGIPLDEKAIVCKIQGYFDAWQALLLKPEFFFKFSWLYKKHKESVKDLKENMEILIEKKRCSIITAEKLEDCMDFATELILAEKRGELTKENVNQCILEMLIAAPDTLSVTVFFMLFLIAKHPQVEEAIVKEIQTVIGERDIRNDDMQKLKVVENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVTLVILLRRFQVQTPQDRCVEKMQKKNDLSLHPDETSGLLEMIFIPRNSDKSLDH

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict79in Ref. 1; AAB51387
Sequence conflict502in Ref. 1; AAB51387

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U92245
EMBL· GenBank· DDBJ
AAB51387.1
EMBL· GenBank· DDBJ
mRNA
AH006583
EMBL· GenBank· DDBJ
AAC48732.1
EMBL· GenBank· DDBJ
Genomic DNA
U52142
EMBL· GenBank· DDBJ
AAB61697.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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