P79430 · CP192_PIG
- ProteinAromatase 2
- GeneCYP19A2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids503 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity
- 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Biological Process | female gonad development | |
Biological Process | response to estradiol |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAromatase 2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionP79430
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000051959 | 1-503 | Aromatase 2 | |||
Sequence: MVLEMLNPMYYKITSMVSEVVPFASIAVLLLTGFLLLLWNYENTSSIPSPGYFLGIGPLISHFRFLWMGIGSACNYYNEMYGEFMRVWIGGEETLIISKSSSVFHVMKHSHYTSRFGSKPGLECIGMYEKGIIFNNDPALWKAVRTYFMKALSGPGLVRMVTVCADSITKHLDKLEEVRNDLGYVDVLTLMRRIMLDTSNNLFLGIPLDEKAIVCKIQGYFDAWQALLLKPEFFFKFSWLYKKHKESVKDLKENMEILIEKKRCSIITAEKLEDCMDFATELILAEKRGELTKENVNQCILEMLIAAPDTLSVTVFFMLFLIAKHPQVEEAIVKEIQTVIGERDIRNDDMQKLKVVENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVTLVILLRRFQVQTPQDRCVEKMQKKNDLSLHPDETSGLLEMIFIPRNSDKSLDH |
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length503
- Mass (Da)58,063
- Last updated1997-05-01 v1
- ChecksumFAC8821A68AC5F77
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 79 | in Ref. 1; AAB51387 | ||||
Sequence: E → K | ||||||
Sequence conflict | 502 | in Ref. 1; AAB51387 | ||||
Sequence: D → E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U92245 EMBL· GenBank· DDBJ | AAB51387.1 EMBL· GenBank· DDBJ | mRNA | ||
AH006583 EMBL· GenBank· DDBJ | AAC48732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U52142 EMBL· GenBank· DDBJ | AAB61697.1 EMBL· GenBank· DDBJ | mRNA |