P79175 · C5AR1_GORGO

Function

function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentbasolateral plasma membrane
Cellular Componentcytoplasmic vesicle
Cellular Componentplasma membrane
Molecular Functioncomplement component C5a receptor activity
Molecular FunctionG protein-coupled receptor activity
Biological Processchemotaxis
Biological Processcomplement receptor mediated signaling pathway
Biological Processinflammatory response
Biological ProcessmRNA transcription by RNA polymerase II
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C5a anaphylatoxin chemotactic receptor 1
  • Alternative names
    • C5a anaphylatoxin chemotactic receptor (C5a-R; C5aR)
  • CD Antigen Name
    • CD88

Gene names

    • Name
      C5AR1
    • Synonyms
      C5AR, C5R1

Organism names

Accessions

  • Primary accession
    P79175
  • Secondary accessions
    • G3QZV7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cytoplasmic vesicle
Note: Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-37Extracellular
Transmembrane38-64Helical; Name=1
Topological domain65-69Cytoplasmic
Transmembrane70-93Helical; Name=2
Topological domain94-110Extracellular
Transmembrane111-132Helical; Name=3
Topological domain133-153Cytoplasmic
Transmembrane154-174Helical; Name=4
Topological domain175-200Extracellular
Transmembrane201-226Helical; Name=5
Topological domain227-242Cytoplasmic
Transmembrane243-265Helical; Name=6
Topological domain266-282Extracellular
Transmembrane283-303Helical; Name=7
Topological domain304-350Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000692081-350C5a anaphylatoxin chemotactic receptor 1
Modified residue11Sulfotyrosine
Modified residue14Sulfotyrosine
Disulfide bond109↔188
Modified residue314Phosphoserine
Modified residue317Phosphoserine
Modified residue327Phosphoserine
Modified residue332Phosphoserine
Modified residue334Phosphoserine
Modified residue338Phosphoserine

Post-translational modification

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. Sulfation at Tyr-14 is important for CHIPS binding.
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to C5a.

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer. May also form higher-order oligomers. Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR. Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region10-18Required for CHIPS binding
Region21-30Involved in C5a binding

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    350
  • Mass (Da)
    39,376
  • Last updated
    2015-01-07 v2
  • Checksum
    5229D43B0D900CFC
MDSFNYTTPDYGHYDDKDTLDPNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEVKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACRILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKQRERAVAVVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAEKTQAV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I2YTC2A0A2I2YTC2_GORGO351

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict57in Ref. 2; CAA66317
Sequence conflict66in Ref. 2; CAA66317
Sequence conflict197in Ref. 2; CAA66317
Sequence conflict204in Ref. 2; CAA66317
Sequence conflict279in Ref. 2; CAA66317
Sequence conflict345in Ref. 2; CAA66317

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X97733
EMBL· GenBank· DDBJ
CAA66317.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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