P79001 · PGPS1_SACPS
- ProteinCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- GenePGS1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids521 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids (By similarity).
Catalytic activity
- a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H+
Pathway
Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity | |
Biological Process | cardiolipin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP79001
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000056826 | 1-521 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | |||
Sequence: MTTRLLQLTRPHYRLLSSPFRKSSIIQRQMSASSPSPANSYLNMITKSLQHNLQTWFHFEPNEIDIIESPSHFYDLLKSKISSSQKRIFIASLYLGKSETELIDCISQALSKNPDLKVSFLLDGLRGTRELPSTCSATLLSSLVAKYGSERVDCRLYKTPAYHGWKKIVVPKRFNEGLGLQHMKIYGFDNEIILSGANLSNDYFTNRQDRYYLFKSANFANYYFKLHQLISSFSYQIVKPKVAGNVNIIWPDSNPTIEPMKNKRKFLREASQLLENFLQISKHNQPISPPGQFSTIVYPISQFTPLFPKYNDKSTEKSTILSLLSNIKNTSISWTFTAGYFNILPEIKANLLATPVTEANVITASPFANGFYQSKGVSSNLPGAYLYLSKKFLQDVSRYNKDQAITLREWQRGVVNKPNGWSYHAKGIWISSRDNNDSDSWKPFITVIGSSNYTRRAYSLDLESNALIITKDEELRNKMKGELNDLLQYTKPVTLEDFKSDPERHVGTGVKIATSVLGKKL |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 177-203 | PLD phosphodiesterase 1 | ||||
Sequence: GLGLQHMKIYGFDNEIILSGANLSNDY | ||||||
Domain | 419-457 | PLD phosphodiesterase 2 | ||||
Sequence: NGWSYHAKGIWISSRDNNDSDSWKPFITVIGSSNYTRRA |
Sequence similarities
Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length521
- Mass (Da)59,354
- Last updated1997-05-01 v1
- Checksum1E28ABDDB2231302