P77672 · LSRC_ECOLI
- ProteinAutoinducer 2 import system permease protein LsrC
- GenelsrC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids342 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity | |
Biological Process | autoinducer AI-2 transmembrane transport | |
Biological Process | quorum sensing |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAutoinducer 2 import system permease protein LsrC
- Short namesAI-2 import system permease protein LsrC
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP77672
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-13 | Periplasmic | ||||
Sequence: MLKFIQNNREITA | ||||||
Transmembrane | 14-34 | Helical | ||||
Sequence: LLAVVLLFVLPGFLDRQYLSV | ||||||
Topological domain | 35-38 | Cytoplasmic | ||||
Sequence: QTLT | ||||||
Transmembrane | 39-59 | Helical | ||||
Sequence: MVYSSAQILILLAMGATLVML | ||||||
Topological domain | 60-69 | Periplasmic | ||||
Sequence: TRNIDVSVGS | ||||||
Transmembrane | 70-90 | Helical | ||||
Sequence: ITGMCAVLLGMLLNAGYSLPV | ||||||
Topological domain | 91-92 | Cytoplasmic | ||||
Sequence: AC | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: VATLLLGLLAGFFNGVLVAWL | ||||||
Topological domain | 114 | Periplasmic | ||||
Sequence: K | ||||||
Transmembrane | 115-135 | Helical | ||||
Sequence: IPAIVATLGTLGLYRGIMLLW | ||||||
Topological domain | 136-156 | Cytoplasmic | ||||
Sequence: TGGKWIEGLPAELKQLSAPLL | ||||||
Transmembrane | 157-177 | Helical | ||||
Sequence: LGVSAIGWLTIILVAFMAWLL | ||||||
Topological domain | 178-212 | Periplasmic | ||||
Sequence: AKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFS | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: LNGCMAALAGIVFASQIGFIP | ||||||
Topological domain | 234-251 | Cytoplasmic | ||||
Sequence: NQTGTGLEMKAIAACVLG | ||||||
Transmembrane | 252-272 | Helical | ||||
Sequence: GISLLGGSGAIIGAVLGAWFL | ||||||
Topological domain | 273-283 | Periplasmic | ||||
Sequence: TQIDSVLVLLR | ||||||
Transmembrane | 284-304 | Helical | ||||
Sequence: IPAWWNDFIAGLVLLAVLVFD | ||||||
Topological domain | 305-342 | Cytoplasmic | ||||
Sequence: GRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA |
Keywords
- Cellular component
Phenotypes & Variants
Miscellaneous
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000060247 | 1-342 | Autoinducer 2 import system permease protein LsrC | |||
Sequence: MLKFIQNNREITALLAVVLLFVLPGFLDRQYLSVQTLTMVYSSAQILILLAMGATLVMLTRNIDVSVGSITGMCAVLLGMLLNAGYSLPVACVATLLLGLLAGFFNGVLVAWLKIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPLLLGVSAIGWLTIILVAFMAWLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIAACVLGGISLLGGSGAIIGAVLGAWFLTQIDSVLVLLRIPAWWNDFIAGLVLLAVLVFDGRLRCALERNLRRQKYARFMTPPPSVKPASSGKKREAA |
Proteomic databases
Expression
Induction
In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter.
Interaction
Subunit
The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length342
- Mass (Da)36,395
- Last updated1997-02-01 v1
- Checksum419E505026ABDE33
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U00096 EMBL· GenBank· DDBJ | AAC74587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAA15201.1 EMBL· GenBank· DDBJ | Genomic DNA |