P77499 · SUFC_ECOLI
- ProteinProbable ATP-dependent transporter SufC
- GenesufC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids248 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
0.29 mM | ATP |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
4.45 μmol/min/mg |
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 34-41 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | iron-sulfur cluster assembly complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | iron-sulfur cluster assembly | |
Biological Process | response to radiation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable ATP-dependent transporter SufC
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionP77499
Proteomes
Subcellular Location
Interaction
Subunit
Part of the SufBCD complex that contains SufB, SufC and SufD. Interacts directly with SufB and SufD. Interacts with SufA (PubMed:19810706).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P77499 | sufA P77667 | 5 | EBI-561601, EBI-1125011 | |
BINARY | P77499 | sufB P77522 | 15 | EBI-561601, EBI-562758 | |
BINARY | P77499 | sufD P77689 | 9 | EBI-561601, EBI-562751 |
Complex viewer
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-246 | ABC transporter | |||
Sequence similarities
Belongs to the ABC transporter superfamily. Ycf16 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length248
- Mass (Da)27,582
- Last updated1997-02-01 v1
- Checksum78FB1108E1850DF9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U00096 EMBL· GenBank· DDBJ | AAC74752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP009048 EMBL· GenBank· DDBJ | BAA15455.1 EMBL· GenBank· DDBJ | Genomic DNA |