P77324 · PAOB_ECOLI

  • Protein
    Aldehyde oxidoreductase FAD-binding subunit PaoB
  • Gene
    paoB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Activity regulation

The complex requires PaoD for activity.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site26-34FAD (UniProtKB | ChEBI)
Binding site108FAD (UniProtKB | ChEBI)
Binding site119[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site129[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site138[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site157[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site164FAD (UniProtKB | ChEBI)
Binding site213FAD (UniProtKB | ChEBI)
Binding site230FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentouter membrane-bounded periplasmic space
Cellular Componentoxidoreductase complex
Cellular Componentperiplasmic space
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarboxylate reductase activity
Molecular FunctionFAD binding
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on the aldehyde or oxo group of donors
Biological Processcatabolic process
Biological Processcellular detoxification of aldehyde

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldehyde oxidoreductase FAD-binding subunit PaoB
  • EC number

Gene names

    • Name
      paoB
    • Synonyms
      yagS
    • Ordered locus names
      b0285, JW0279

Organism names

  • Taxonomic identifier
  • Strains
    • K12 / MG1655 / ATCC 47076
    • K12 / W3110 / ATCC 27325 / DSM 5911
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    P77324
  • Secondary accessions
    • Q2MCD7

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001660941-318Aldehyde oxidoreductase FAD-binding subunit PaoB

Proteomic databases

Interaction

Subunit

Heterotrimer composed of PaoA, PaoB and PaoC.
View interactors in UniProtKB
View CPX-4281 in Complex Portal

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-223FAD-binding PCMH-type

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    33,858
  • Last updated
    1997-02-01 v1
  • Checksum
    7D51C2B30C9BB222
MKAFTYERVNTPAEAALSAQRVPGAKFIAGGTNLLDLMKLEIETPTHLIDVNGLGLDKIEVTDAGGLRIGALVRNTDLAAHERVRRDYAVLSRALLAGASGQLRNQATTAGNLLQRTRCPYFYDTNQPCNKRLPGSGCAALEGFSRQHAVVGVSEACIATHPSDMAVAMRLLDAVVETITPEGKTRSITLADFYHPPGKTPHIETALLPGELIVAVTLPPPLGGKHIYRKVRDRASYAFALVSVAAIIQPDGSGRVALGGVAHKPWRIEAADAQLSQGAQAVYDTLFASAHPTAENTFKLLLAKRTLASVLAEARAQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U73857
EMBL· GenBank· DDBJ
AAB18014.1
EMBL· GenBank· DDBJ
Genomic DNA
U00096
EMBL· GenBank· DDBJ
AAC73388.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009048
EMBL· GenBank· DDBJ
BAE76069.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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